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辅肌动蛋白.
辅肌动蛋白(英语:Actinin)是一种微丝蛋白。α-辅肌动蛋白1是骨骼肌细胞中肌动蛋白附着于Z线所必须的[1],也是其在平滑肌中附于电子致密部分所需。起功能的辅肌动蛋白是反向平行的二聚体,在肌节的细肌丝之间交叉链接。
非肌节特异性的α-辅肌动蛋白(ACTN1和ACTN4)在组织中广泛表达,棒状的α-辅肌动蛋白二聚体的两个末端都包含有肌动蛋白结合结构域。
ACTN4上的突变可造成肾脏疾病局灶性节段性肾小球硬化症。
- ^ Ganong's Review of Medical Physiology, 24th Edition. Lange (Tata McGraw Hill). 2012: 100.
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