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钙结合蛋白

钙结合蛋白(英语:Calcium-binding proteinsCaBP)是一类在细胞钙信号转导中与Ca2+结合的蛋白质

最普遍的Ca2+传感蛋白是在所有真核生物中都有发现的钙调素

细胞内Ca2+肌质网中的存储与释放与一种高效,低亲和性的钙离子结合蛋白肌钙集蛋白英语calsequestrin相关[1]

因其在信号转导中的作用,钙结合蛋白几乎在细胞功能的所有方面都有所贡献,从内环境稳定直到学习与记忆能力。

例如,神经元特异性的calexcitin能刺激神经元兴奋,并与控制神经元电位的蛋白质(如电压门控钾离子通道)相互作用[2]

另见

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参考文献

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  1. ^ Siegel, George (Ed.). Basic neurochemistry : molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X
  2. ^ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D. Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability. PNAS. 1996, 93 (24): 13808–13. PMC 19433可免费查阅. PMID 8943017. doi:10.1073/pnas.93.24.13808. 

3. Yáñez M, Gil-Longo J, Campos-Toimil M. Calcium binding proteins. Adv Exp Med Biol. 2012;740:461-82.页面存档备份,存于互联网档案馆) doi: 10.1007/978-94-007-2888-2_19.

外部链接

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钙结合蛋白
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