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真核延伸因子2

Eukaryotic translation elongation factor 2
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 EEF2; EEF-2; EF-2; EF2; SCA26
扩展标识 遗传学130610 鼠基因95288 同源基因134867 ChEMBL: 1795108 GeneCards: EEF2 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 1938 13629
Ensembl ENSG00000167658 ENSMUSG00000034994
UniProt P13639 P58252
mRNA序列 NM_001961 NM_007907
蛋白序列 NP_001952 NP_031933
基因位置 Chr 19:
3.98 – 3.99 Mb
Chr 10:
81.18 – 81.18 Mb
PubMed查询 [1] [2]

真核延伸因子2(英语:Eukaryotic elongation factor 2eEF2)是一种蛋白质,由人类基因 EEF2 编码。[1][2]

这个基因编码的蛋白质是GTP结合翻译延伸因子家族的一员。这种蛋白质是蛋白质合成过程的一个重要组成部分,它促进GTP依赖的核糖体易位。这种蛋白质可由EF-2激酶英语Elongation factor 2 kinase磷酸化而失活。

在常见的细菌感染中,真核延伸因子2是白喉毒素(源自白喉杆菌英语Corynebacterium diphtheriae),以及外毒素A(源自绿脓杆菌)的抑制对象。[3]

参考文献

  1. ^ Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. Biol Chem Hoppe Seyler. Mar 1990, 370 (10): 1071–5. PMID 2610926. doi:10.1515/bchm3.1989.370.2.1071. 
  2. ^ Chromosomal assignment of the gene for human elongation factor 2. Proc Natl Acad Sci U S A. Jul 1984, 81 (10): 3158–62. PMC 345240可免费查阅. PMID 6427766. doi:10.1073/pnas.81.10.3158. 
  3. ^ The life and death of translation elongation factor 2. Biochem. Soc. Trans. February 2006, 34 (Pt 1): 1–6 [2016-11-02]. PMID 16246167. doi:10.1042/BST20060001. (原始内容存档于2020-03-25). 
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真核延伸因子2
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