约翰·富兰克林·塞恩(英语:John Franklin Sain,1917年9月25日—2006年11月7日),为美国职棒大联盟的投手。生涯曾效力过勇士、洋基与运动家等队。他最有名的就是于1946年至1951年与华伦·史潘组成勇士队的双强投。1948年,他在国联MVP票选中拿下第二名。后来他退休后也成为了一位有名的投手教练。
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