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嵌入 (化学)

发生于图中红色区域的嵌入作用使DNA长链扭曲变形。

嵌入(英语:Intercalation,或译插层)在化学上是指在两个分子或基团之间加入一个分子,过程可逆。例如DNA嵌入与石墨层间化合物(graphite intercalation compound)。

DNA嵌入

有许多分子可与生物体内的DNA发生交互作用,以配体为例,嵌入是配体分子与DNA的一种结合方式,当配体大小符合碱基对之间的空隙时,就有可能发生嵌入。通常嵌入DNA的配体是多环类、芳香类,或是平面分子。常见的例子包括溴化乙锭、原黄素(proflavine)、道诺霉素(daunomycin)、阿霉素(doxorubicin)、沙利窦迈(thalidomide)等。这些物质可应用于化学治疗,抑制癌细胞的生长。

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嵌入 (化学)
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