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促肾上腺皮质激素

阿黑皮素原(β-促脂解素/α-促黑[细胞激]素/β-促黑[细胞激]素/β-内啡肽)
阿黑皮素原衍生物
POMC
     
γ-MSH ACTH β-促脂解素
         
  α-MSH CLIP γ-促脂解素 β-内啡肽
       
    β-MSH  
识别
符号 POMC
Entrez 5443
HUGO 9201
OMIM 176830
RefSeq NM_000939
UniProt P01189
其他数据
基因座 2 p23

促肾上腺皮质激素(英语:adrenocorticotropic hormone, ACTH)——或简称促皮质素corticotropin)——是一种多肽促激素并分泌于脑垂体前叶[1],是下丘脑-脑垂体-肾上腺皮质轴(hypothalamic-pituitary-adrenal axis)中的重要化学物质。其主要作用是增加肾上腺皮质皮质醇的分泌和释放,ACTH也与许多生物体的昼夜节律有关。[2]

功能

ACTH经由主要位于肾上腺细胞表面上的ACTH受体,来刺激肾上腺皮质合成多种皮质类固醇,其中主要是糖皮质激素,其他还有雄性素等性激素。

  1. ^ Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. December 6, 2012: 84–. ISBN 978-94-011-4439-1. 
  2. ^ Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks (PDF). Annual Review of Physiology. 2010, 72: 517–49 [2021-07-03]. PMID 20148687. doi:10.1146/annurev-physiol-021909-135821. (原始内容存档 (PDF)于2021-04-14). 
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促肾上腺皮质激素
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