Proteaza
Proteaza (peptidaza, proteinaza) je enzim koji izvodi proteolizu. Proteaza započinje proteinski katabolizam hidrolizom peptidnih veza koje povezuju aminokiseline u polipeptidne lance od kojih je formiran protein.[1][2]
Klasifikacija
[уреди | уреди извор]Standard
[уреди | уреди извор]Proteaze se dele u šest grupa:
- Serinske proteaze
- Treoninske proteaze
- Cisteinske proteaze
- Aspartatne proteaze
- Metaloproteaze
- Glutamatne proteaze
Treoninske i glutamatne proteaze nisu bile poznate do 1995 i 2004, respektivno. Mehanizam raskidanja peptidne veze obuhvata korak u kome nukleofil napada peptidnu vezu. Nukleofil je bilo aminokiselina peptidaze (cistein, serin, treonin) ili molekul vode kod aspartat-, metalo- i glutamatne proteaze. Jedan način formiranja nukleofila je putem katalitičke trijade, gde se histidinski ostatak koristi za aktivaciju serina, cisteina, ili treonina.
Reference
[уреди | уреди извор]- ^ Donald Voet; Judith G. Voet (2005). Biochemistry (3 изд.). Wiley. ISBN 9780471193500.
- ^ Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Literatura
[уреди | уреди извор]- Barrett A.J., Rawlings ND, Woessner JF. The Handbook of Proteolytic Enzymes, 2nd ed. Academic Press, 2003. ISBN 0-12-079610-4.
- Hedstrom L. Serine Protease Mechanism and Specificity. Chem Rev 2002;102:4501-4523.
- Southan C. A genomic perspective on human proteases as drug targets. Drug Discov Today 2001;6:681-688.
- Hooper NM. Proteases in Biology and Medicine. London: Portland Press, 2002. ISBN 1-85578-147-6.
- Puente XS, Sanchez LM, Overall CM, Lopez-Otin C. Human and Mouse Proteases: a Comparative Genomic Approach. Nat Rev Genet 2003;4:544-558.
- Ross J, Jiang H, Kanost MR, Wang Y. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Gene 2003;304:117-31.
- Puente XS, Lopez-Otin C. A Genomic Analysis of Rat Proteases and Protease Inhibitors. Genome Biol 2004;14:609-622.
- Lucía Feijoo-Siota, Tomás G. Villa Native and Biotechnologically Engineered Plant Proteases with Industrial Applications. Food and Bioprocess Technology 2010.
* Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Međunarodno udruženje za proteolizu
- Baza podataka peptidaza Архивирано на сајту Wayback Machine (14. новембар 2006)
| Kičmenjačke | |
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| Patogene |
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| Biljne | |
| Katepsin | |
| 3.4.11-19: Egzopeptidaza |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3.4.21-24: Endopeptidaza | Serinske peptidaze · Cisteinska proteaza · Aspartatna proteaza · Metaloendopeptidaze Druge/negrupisane: Sekretaza amiloidnog prekursornog proteina (Alfa-sekretaza, Beta-sekretaza 1, Beta-sekretaza 2, Gama sekretaza) | ||||||||||||||
| 3.4.99: Nepoznato | Stafilokinaza | ||||||||||||||
| Teme | |
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| Tipovi | |
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