Polo kinaza

Identifikatori

Baze podataka

IntEnz

Strukture PBP

RCSB PDB PDBe PDBj PDBsum

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Polo kinaza (EC 2.7.11.21, Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, polo serin-treonin kinaza, polo-like kinaza, polo-like kinaza 1, serin/treonin-specifična Drosophila kinaza polo, STK21) je enzim sa sistematskim imenom ATP:proteinska fosfotransferaza (spindle-pole-zavisna).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + protein

\rightleftharpoons

ADP + fosfoprotein

Ovaj enzim vezuje pol vretena tokom mitoze i ima važnu ulogu tokom hromozomne segregacije.

Reference

[уреди | уреди извор]

^ Llamazares, S., Moreira, A., Tavares, A., Girdham, C., Spruce, B.A., Gonzalez, C., Karess, R.E., Glover, D.M. and Sunkel, C.E. (1991). „polo encodes a protein kinase homolog required for mitosis in Drosophila”. Gene. 5: 2153—2165. PMID 1660828.
^ Golsteyn, R.M., Mundt, K.E., Fry, A.M. and Nigg, E.A. (1995). „Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function”. J. Cell Biol. 129: 1617—1628. PMID 7790358.
^ Mulvihill, D.P. & Hyams, J.S. (2002). „Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint. J”. Cell. 115: 3575—3586. PMID 12186944.
^ Ohkura, H. (2003). „Phosphorylation: polo kinase joins an elite club”. Curr. Biol. 13: R912—R914. PMID 14654016.

Literatura

[уреди | уреди извор]

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

[уреди | уреди извор]

Polo+kinase на US National Library of Medicine Medical Subject Headings (MeSH)

Kinaze: Serin/treonin-specifične proteinske kinaze (EC 2.7.11-12)

(1) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.1-EC 2.7.11.20)

Nespecifična serin/treonin proteinske kinaze (EC 2.7.11.1)	LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Proteinska kinaza B (AKT1, AKT2, AKT3), Ataksija telangiektazija mutirani, Sisarski cilj rapamicina, EIF-2 kinaze (PKR, HRI), Wee1 (WEE1)
Piruvat dehidrogenazna kinaza (EC 2.7.11.2)	PDK1, PDK2, PDK3
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3)	AMP-activated protein kinase,
(3-metil-2-oksobutanoat dehidrogenaza (prenos acetila)) (EC 2.7.11.4)	BCKDK, BCKDHA, BCKDHB
(izocitrat dehidrogenaza (NADP+)) kinaza (EC 2.7.11.5)	IDH2, IDH3A, IDH3B, IDH3G
tirozin 3-monooksigenazna kinaza (EC 2.7.11.6)	STK4
Miozin-teški-lanac kinaza (EC 2.7.11.7)	Aurora kinaza (Aurora A kinaza, Aurora B kinaza)
Fas-aktivirana serin/treoninska kinaza (EC 2.7.11.8)	FASTK, STK10
Goodpasture-antigen-vezujuća proteinska kinaza (EC 2.7.11.9)	-
IκB kinaza (EC 2.7.11.10)	CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP
cAMP-zavisna proteinska kinaza (EC 2.7.11.11)	Proteinska kinaza A, PRKACG, PRKACB, PRKACA, PRKY
cGMP-zavisna proteinska kinaza (EC 2.7.11.12)	Proteinska kinaza G, PRKG1
Protein kinaza C (EC 2.7.11.13)	Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Proteinska zavisna proteinska N1, PKN2, PKN3,
Rodopsinska kinaza (EC 2.7.11.14)	Rodopsinska kinaza
Beta adrenergički receptor kinaza (EC 2.7.11.15)	Beta adrenergički receptor kinaza, Beta adrenergički receptor kinaza-2
G protein spregnuti receptor kinaza (EC 2.7.11.16)	GRK4, GRK5, GRK6
Ca2+/kalmodulin-zavisna (EC 2.7.11.17)	BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1
Miozin laki-lanac kinaza (EC 2.7.11.18)	MYLK, MYLK2, MYLK3, MYLK4
Fosforilazna kinaza (EC 2.7.11.19)	PHKA1, PHKA2, PHKB, PHKG1, PHKG2
Faktor elongacije 2 kinaza (EC 2.7.11.20)	EEF2K, STK19
Polo kinaza (EC 2.7.11.21)	PLK1, PLK2, PLK3, PLK4

(2) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.21-EC 2.7.11.30)

Polo kinaza (EC 2.7.11.21)	PLK1, PLK2, PLK3, PLK4
Ciklin-zavisna kinaza (EC 2.7.11.22)	CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1
(RNK-polimerazna)-podjedinica kinaza (EC 2.7.11.23)	RPS6KA5, RPS6KA4, P70S6 kinaza, P70-S6 kinaza 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1
Mitogenom-aktivirana proteinska kinaza (EC 2.7.11.24)	Ekstracelularnim signalom regulisane (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogenom-aktivirani protein (MAPK11, MAPK13, MAPK14)
MAP3K (EC 2.7.11.25)	MAP kinaza kinaza kinaze (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLK (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14
Tau-proteinska kinaza (EC 2.7.11.26)	TPK1, TTK, GSK-3
acetil-CoA karboksilazna kinaza] (EC 2.7.11.27)	-
Tropomiozinska kinaza (EC 2.7.11.28)	-
Receptor lipoproteina-niske-gustine kinaza (EC 2.7.11.29)	-
Receptor protein serin/treonin kinaza (EC 2.7.11.30)	Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Mulerianski hormonski receptor

(3) Kinaze dualne-specifičnosti (EC 2.7.12)

MAP2K	MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Категорија

Polo kinaza

Reference

Literatura

Spoljašnje veze

Suggest as cover photo

Thank you for helping!

Install Wikiwand

Don't forget to rate us

Tell your friends about Wikiwand!

Enjoying Wikiwand?

Tell your friends and spread the love:

Your preferred languages

All languages

Follow Us

Don't forget to rate us

Our magic isn't perfect

Thank you for helping!

Oh no, there's been an error