Ciklin-zavisna kinaza

Ciklin-zavisna kinaza (EC 2.7.11.22, Bur1, Bur1 Cdk, Cak1, Cak1p, cdc2, cdc2 kinaza, Cdc28p, CDK, cdk-aktivirajuća kinaza, Cdk-aktivirajuća proteinska kinaza, cdk1, cdk2, Cdk2, cdk3, cdk4, cdk5, cdk6, cdk7, cdk8, cdk9, ciklin A-aktivirajući cdc2, ciklin A-aktivirajući cdk2, ciklin D-cdk6 kinaza, ciklin D-zavisni kinaza, ciklin E kinaza, ciklin-A vezana kinaza, ciklin-zavisna kinaza 6, ciklin-zavisna kinaza-2, ciklin-zavisna kinaza-4, ciklin-zavisna protein kinaza aktivirajuća kinaza, cyk, D-tip ciklinska kinaza, nclk, neuronal cdc2-slična kinaza, PCTAIRE-1, STK25) je enzim sa sistematskim imenom ATP:ciklin fosfotransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + protein

\rightleftharpoons

ADP + fosfoprotein

Za aktivaciju ciklin-zavisne kinaze neophodno je vezivanje enzima sa regulatornom podjedinicom, ciklinom.

Reference

[уреди | уреди извор]

^ Johnson, D.G. & Walker, C.L. (1999). „Cyclins and cell cycle checkpoints”. Annu. Rev. Pharmacol. Toxicol. 39: 295—312. PMID 10331086.
^ Pan, Z.Q., Amin, A. and Hurwitz, J. (1993). „Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities”. J. Biol. Chem. 268: 20443—20451. PMID 8397207.
^ Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L. (1996). „Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit”. J. Biol. Chem. 271: 471—477. PMID 8550604.

Literatura

[уреди | уреди извор]

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

[уреди | уреди извор]

Cyclin-dependent+kinase на US National Library of Medicine Medical Subject Headings (MeSH)

Kinaze: Serin/treonin-specifične proteinske kinaze (EC 2.7.11-12)

(1) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.1-EC 2.7.11.20)

Nespecifična serin/treonin proteinske kinaze (EC 2.7.11.1)	LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Proteinska kinaza B (AKT1, AKT2, AKT3), Ataksija telangiektazija mutirani, Sisarski cilj rapamicina, EIF-2 kinaze (PKR, HRI), Wee1 (WEE1)
Piruvat dehidrogenazna kinaza (EC 2.7.11.2)	PDK1, PDK2, PDK3
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3)	AMP-activated protein kinase,
(3-metil-2-oksobutanoat dehidrogenaza (prenos acetila)) (EC 2.7.11.4)	BCKDK, BCKDHA, BCKDHB
(izocitrat dehidrogenaza (NADP+)) kinaza (EC 2.7.11.5)	IDH2, IDH3A, IDH3B, IDH3G
tirozin 3-monooksigenazna kinaza (EC 2.7.11.6)	STK4
Miozin-teški-lanac kinaza (EC 2.7.11.7)	Aurora kinaza (Aurora A kinaza, Aurora B kinaza)
Fas-aktivirana serin/treoninska kinaza (EC 2.7.11.8)	FASTK, STK10
Goodpasture-antigen-vezujuća proteinska kinaza (EC 2.7.11.9)	-
IκB kinaza (EC 2.7.11.10)	CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP
cAMP-zavisna proteinska kinaza (EC 2.7.11.11)	Proteinska kinaza A, PRKACG, PRKACB, PRKACA, PRKY
cGMP-zavisna proteinska kinaza (EC 2.7.11.12)	Proteinska kinaza G, PRKG1
Protein kinaza C (EC 2.7.11.13)	Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Proteinska zavisna proteinska N1, PKN2, PKN3,
Rodopsinska kinaza (EC 2.7.11.14)	Rodopsinska kinaza
Beta adrenergički receptor kinaza (EC 2.7.11.15)	Beta adrenergički receptor kinaza, Beta adrenergički receptor kinaza-2
G protein spregnuti receptor kinaza (EC 2.7.11.16)	GRK4, GRK5, GRK6
Ca2+/kalmodulin-zavisna (EC 2.7.11.17)	BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1
Miozin laki-lanac kinaza (EC 2.7.11.18)	MYLK, MYLK2, MYLK3, MYLK4
Fosforilazna kinaza (EC 2.7.11.19)	PHKA1, PHKA2, PHKB, PHKG1, PHKG2
Faktor elongacije 2 kinaza (EC 2.7.11.20)	EEF2K, STK19
Polo kinaza (EC 2.7.11.21)	PLK1, PLK2, PLK3, PLK4

(2) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.21-EC 2.7.11.30)

Polo kinaza (EC 2.7.11.21)	PLK1, PLK2, PLK3, PLK4
Ciklin-zavisna kinaza (EC 2.7.11.22)	CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1
(RNK-polimerazna)-podjedinica kinaza (EC 2.7.11.23)	RPS6KA5, RPS6KA4, P70S6 kinaza, P70-S6 kinaza 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1
Mitogenom-aktivirana proteinska kinaza (EC 2.7.11.24)	Ekstracelularnim signalom regulisane (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogenom-aktivirani protein (MAPK11, MAPK13, MAPK14)
MAP3K (EC 2.7.11.25)	MAP kinaza kinaza kinaze (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLK (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14
Tau-proteinska kinaza (EC 2.7.11.26)	TPK1, TTK, GSK-3
acetil-CoA karboksilazna kinaza] (EC 2.7.11.27)	-
Tropomiozinska kinaza (EC 2.7.11.28)	-
Receptor lipoproteina-niske-gustine kinaza (EC 2.7.11.29)	-
Receptor protein serin/treonin kinaza (EC 2.7.11.30)	Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Mulerianski hormonski receptor

(3) Kinaze dualne-specifičnosti (EC 2.7.12)

MAP2K	MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Категорија

Ciklin-zavisna kinaza

Reference

Literatura

Spoljašnje veze

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