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Caja E2

La caja E2 es el nombre de una secuencia reguladora que es parte del gen de la insulina.[1]​ La secuencia, conocida como parte de los elementos E del gen de la insulina, está compuesta por una secuencia conservada CANNTG, inmediatamente aguas abajo de la caja A5.[2]​ En ratas, la mutación o deleción de la caja E2 produce una pérdida significativa de las funciones del promotor de la insulilna y cuando existe mutación tanto de la caja E2 como la caja E1, el promotor queda completamente inhabilitado.[2]​ En los promotores de la insulina entre los diferentes mamíferos, a diferencia de la caja E1, la secuencia de la caja E2 no está bien conservada.

Véase también

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Referencias

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  1. Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription
  2. a b LeRoith, Derek; Jerrold M. Olefsky (2003). Diabetes mellitus (3ra edición). Lippincott Williams & Wilkins. p. 16. ISBN 0781740975.  |autor1= y |apellidos= redundantes (ayuda)
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Caja E2
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