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Caja A5

La caja A5 es el nombre de una secuencia reguladora que es parte del gen de la insulina.[1]​ La secuencia, conocida como parte de los elementos A del gen de la insulina, está compuesta por cortos grupos ricos en adenosina y timidina, inmediatamente aguas arriba de la caja E2.[2]​ En ratas, la mutación o deleción de la caja A5 no ha producido pérdida de las funciones de la molécula de la insulilna, a diferencia de lo que ocurre con la caja A3.[2]

Referencias

[editar]
  1. Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription
  2. a b LeRoith, Derek; Simeon I. Taylor; Jerrold M. Olefsky (2003). Diabetes mellitus (3ra edición). Lippincott Williams & Wilkins. p. 16. ISBN 0781740975. 
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Caja A5
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