TRAM2

TRAM2
Identifikatori
Aliasi	TRAM2
Vanjski ID-jevi	OMIM: 608485 MGI: 1924817 HomoloGene: 8183 GeneCards: TRAM2
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	52,577,060 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	21,149,453 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• membrana; • integral component of membrane; • rough endoplasmic reticulum;
Biološki proces	• protein transport; • collagen biosynthetic process; • protein insertion into ER membrane; • SRP-dependent cotranslational protein targeting to membrane, translocation;
	Izvori:Amigo / QuickGO
Ortolozi
	9697
	170829
	ENSG00000065308
	ENSMUSG00000041779
	Q15035
	Q924Z5
	NM_012288
	NM_177409
	NP_036420
	NP_803128
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Membranski protein 2 na translokacijskom lancu jest protein koji je kod ljudi kodiran genom TRAM2.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 370 aminokiselina, а molekulska težina 43.328 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAFRRRTKSY	PLFSQEFVIH	NHADIGFCLV	LCVLIGLMFE	VTAKTAFLFI
LPQYNISVPT	ADSETVHYHY	GPKDLVTILF	YIFITIILHA	VVQEYILDKI
SKRLHLSKVK	HSKFNESGQL	VVFHFTSVIW	CFYVVVTEGY	LTNPRSLWED
YPHVHLPFQV	KFFYLCQLAY	WLHALPELYF	QKVRKEEIPR	QLQYICLYLV
HIAGAYLLNL	SRLGLILLLL	QYSTEFLFHT	ARLFYFADEN	NEKLFSAWAA
VFGVTRLFIL	TLAVLAIGFG	LARMENQAFD	PEKGNFNTLF	CRLCVLLLVC
AAQAWLMWRF	IHSQLRHWRE	YWNEQSAKRR	VPATPRLPAR	LIKRESGYHE
NGVVKAENGT	SPRTKKLKSP

Funkcija

TRAM2 je komponenta translokona, zatvorenog makromolekulskog kanala koji kontrolira posttranslacijsku obradu nastajućih sekretornih i membranskih proteina na membrani endoplazmatskog retikuluma (ER).^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065308 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041779 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
^ Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.
^ ^a ^b "Entrez Gene: TRAM2 translocation associated membrane protein 2".
^ "UniProt, Q15035" (jezik: engleski). Pristupljeno 5. 10. 2021.

Dopunska literatura

Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription". Mol. Cell. Biol. 23 (23): 8773–85. doi:10.1128/MCB.23.23.8773-8785.2003. PMC 262660. PMID 14612417.
Stefanovic B, Stefanovic L, Schnabl B, et al. (2004). "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis". Mol. Cell. Biol. 24 (4): 1758–68. doi:10.1128/MCB.24.4.1758-1768.2004. PMC 344171. PMID 14749390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Kategorije

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065308 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041779 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7584044-5] Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

[pmid10594243-6] Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.

[entrez-7] "Entrez Gene: TRAM2 translocation associated membrane protein 2".

[UniProt-8] "UniProt, Q15035" (jezik: engleski). Pristupljeno 5. 10. 2021.

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TRAM2

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura

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