TM4SF1
TM4SF1 | |||||||||||||||||||||||||
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Identifikatori | |||||||||||||||||||||||||
Aliasi | TM4SF1 | ||||||||||||||||||||||||
Vanjski ID-jevi | OMIM: 191155 MGI: 104678 HomoloGene: 7409 GeneCards: TM4SF1 | ||||||||||||||||||||||||
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Ortolozi | |||||||||||||||||||||||||
Vrste | Čovjek | Miš | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNK) | |||||||||||||||||||||||||
RefSeq (bjelančevina) | |||||||||||||||||||||||||
Lokacija (UCSC) | Chr 3: 149.37 – 149.38 Mb | Chr 3: 57.19 – 57.21 Mb | |||||||||||||||||||||||
PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
Wikipodaci | |||||||||||||||||||||||||
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Član 1 porodice 4 L6 transmembranskih proteina jest protein koji je kod ljudi kodiran genom TM4SF1 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 202 aminokiseline, а molekulska težina 21.632 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
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MCYGKCARCI | GHSLVGLALL | CIAANILLYF | PNGETKYASE | NHLSRFVWFF | ||||
SGIVGGGLLM | LLPAFVFIGL | EQDDCCGCCG | HENCGKRCAM | LSSVLAALIG | ||||
IAGSGYCVIV | AALGLAEGPL | CLDSLGQWNY | TFASTEGQYL | LDTSTWSECT | ||||
EPKHIVEWNV | SLFSILLALG | GIEFILCLIQ | VINGVLGGIC | GFCCSHQQQY | ||||
DC |
Funkcija
Protein kodiran ovim genom je član natporodice 4 transmembranskih proteina, poznate i kao porodica tetraspanina . Većina ovih članova su proteini na površini ćelije koje karakteriše prisustvo četiri hidrofobna domena. Proteini posreduju u događajima transdukcije signala koji imaju ulogu u regulaciji razvoja, aktivacije, rasta i pokretljivosti ćelija. Ovaj kodirani protein je antigen ćelijske površine i visoko je eksprimiran u različitim karcinomima.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169908 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027800 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.
- ^ a b "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".
- ^ "UniProt, P30408" (jezik: engleski). Pristupljeno 2. 11. 2021.
Dopunska literatura
- Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, Hellström KE, Aruffo A (Mar 1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". The Journal of Biological Chemistry. 269 (10): 7397–401. doi:10.1016/S0021-9258(17)37298-8. PMID 7510285.
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
- Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–34. doi:10.1007/BF00189229. PMID 8168850. S2CID 22971645.
- Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J (Dec 2000). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Molecular Biology of the Cell. 11 (12): 4217–25. doi:10.1091/mbc.11.12.4217. PMC 15068. PMID 11102519.
- Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J (Jul 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
- Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N (Dec 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–8. PMID 11774983.
- Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–16. PMID 12855661.
- Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828. S2CID 26010618.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC (Jun 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14 (8): 1868–76. doi:10.1158/1535-7163.MCT-15-0188. PMID 26089370.
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