PKIA
cAMP-ovisni inhibitor alfa protein-kinaze je protein koji je kod ljudi kodiran genom PKIA.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 76 aminokiselina, а molekulska težina 7.989 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTDVETTYAD | FIASGRTGRR | NAIHDILVSS | ASGNSNELAL | KLAGLDINKT | ||||
| EGEEDAQRSS | TEQSGEAQGE | AAKSES |
Funkcija
Protein kodiran ovim genom član je porodice inhibitora protein kinaze (PKA) ovisne o cAMP-u. Pokazalo se da ovaj protein stupa u interakciju i inhibira aktivnosti katalitskih podjedinica C alfa i C beta PKA. Prijavljene su Alternativno prerađene varijante transkripta, koje kodiraju isti protein.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171033 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027499 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Olsen SR, Uhler MD (Feb 1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol. 5 (9): 1246–1256. doi:10.1210/mend-5-9-1246. PMID 1770951.
- ^ a b "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha".
- ^ "UniProt, P61925" (jezik: engleski). Pristupljeno 20. 9. 2021.
Dopunska literatura
- Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase". J. Biol. Chem. 266 (17): 11158–11162. doi:10.1016/S0021-9258(18)99142-8. PMID 1710219.
- Knighton DR, Zheng JH, Ten Eyck LF, et al. (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science. 253 (5018): 414–420. doi:10.1126/science.1862343. PMID 1862343.
- Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase". J. Biol. Chem. 262 (7): 3398–3403. doi:10.1016/S0021-9258(18)61516-9. PMID 2434500.
- Scott JD, Fischer EH, Demaille JG, Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 82 (13): 4379–4383. doi:10.1073/pnas.82.13.4379. PMC 390417. PMID 2989819.
- Scott JD, Glaccum MB, Fischer EH, Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1613–1616. doi:10.1073/pnas.83.6.1613. PMC 323133. PMID 3456605.
- Wen W, Taylor SS, Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated". J. Biol. Chem. 270 (5): 2041–2046. doi:10.1074/jbc.270.5.2041. PMID 7836431.
- Baude EJ, Dignam SS, Olsen SR, et al. (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor". J. Biol. Chem. 269 (3): 2316–2323. doi:10.1016/S0021-9258(17)42170-3. PMID 7905001.
- Baude EJ, Dignam SS, Reimann EM, Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors". J. Biol. Chem. 269 (27): 18128–18133. doi:10.1016/S0021-9258(17)32426-2. PMID 8027074.
- Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol. 6 (7): 848–854. doi:10.1016/S0960-9822(02)00608-5. PMID 8805303. S2CID 16705807.
- Zimmermann B, Chiorini JA, Ma Y, et al. (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I". J. Biol. Chem. 274 (9): 5370–5378. doi:10.1074/jbc.274.9.5370. PMID 10026146.
- Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–149. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gassel M, Breitenlechner CB, Rüger P, et al. (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol. 329 (5): 1021–1034. doi:10.1016/S0022-2836(03)00518-7. PMID 12798691.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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