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Fosfoinozitol

Inozitol
Fosfatna grupa

Fosfoinozitoli ili Inozitol fosfati su grupa mono- do poli fosforilacijskih inozitola. Oni imaju ključnu ulogu u različitim ćelijskim funkcijama, kao što su rast ćelija, apoptoza, migracija ćelija, endocitoza i ćelijska diferencijacija.[1][2][3]

Grupa se sastoji od:

  • Inozitol monofosfata (IP)
  • Inozitol bisfosfata (IP2)
  • inozitol trifosfata (IP3)
  • Inozitol pentakisfosfata (IP5)
  • Inozitol heksafosfata (IP6) također poznat kao fitinska kiselina ili fitini (kao soli).[4] and Steger[5] (both in Science Magazine).

Funkcije

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Inozitol trifosfat

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Inozitol trisphosfati aktiviraju inozitol trifosfat receptor za oslobađanje kalcija u citoplazmi.

Ostali

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Inozitol tetrafosfati, Inozitol pentakisfosfati i heksa-fosfati su upleteni u ekspresiju gena.

Također pogledajte

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Reference

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  1. ^ Kapur Pojskić L., Ed. (2014): Uvod u genetičko inženjerstvo i biotehnologiju, 2. izdanje. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 978-9958-9344-8-3.
  2. ^ Alberts B. (2002)ː Molecular biology of the cell. Garland Science, New York, ISBN 0-8153-3218-1.
  3. ^ Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, ISBN 9958-9344-1-8.
  4. ^ Shen, X; Xiao, H; Ranallo, R; Wu, WH; Wu, C (2003). "Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates". Science. 299 (5603): 112–4. doi:10.1126/science.1078068. PMID 12434013.
  5. ^ Steger, DJ; Haswell, ES; Miller, AL; Wente, SR; O'Shea, EK (2003). "Regulation of chromatin remodeling by inositol polyphosphates". Science. 299 (5603): 114–6. doi:10.1126/science.1078062. PMC 1458531. PMID 12434012.

Vanjski linkovi

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Fosfoinozitol
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