FRAT2
| FRAT2 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | FRAT2 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 605006 MGI: 2673967 HomoloGene: 8095 GeneCards: FRAT2 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl | |||||||||||||||||||||||||
| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 10: 97.33 – 97.33 Mb | Chr 19: 41.83 – 41.84 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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GSK-3-vezujući protein FRAT2 je protein koji je kod ljudi kodiran genom FRAT2.[5][6][7]
Protein kodiran ovim bezintronskim genom pripada porodici proteina koji se vezuju za GSK-3. Studije pokazuju da ovaj protein ima ulogu pozitivnog regulatora WNT-signalnog puta. Može se povećati u progresiji tumora.[7]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 233 aminokiseline, а molekulska težina 24.051 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPCRREEEEE | AGEEAEGEEE | EDDSFLLLQQ | SVTLGSSGEV | DRLVAQIGET | ||||
| LQLDAAQDSP | ASPCAPPGVP | LRAPGPLAAA | VPADKARPPA | VPLLLPPASA | ||||
| ETVGPAPSGA | LRCALGDRGR | VRGRAAPYCV | AEVAAGPSAL | PGPCRRGWLR | ||||
| DAVTSRRLQQ | RRWTQAGARA | GDDDPHRLLQ | QLVLSGNLIK | EAVRRLQRAV | ||||
| AAVAATGPAS | APGPGGGRSG | PDRIALQPSG | SLL |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000181274 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047604 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. S2CID 17951152.
- ^ Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
- ^ a b "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".
- ^ "UniProt, O75474". Pristupljeno 2. 9. 2021.
Dopunska literatura
[uredi | uredi izvor]- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
- Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stoothoff WH, Cho JH, McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation". J. Biol. Chem. 280 (1): 270–6. doi:10.1074/jbc.M410061200. PMID 15522877.
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