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FBXO16

FBXO16
Identifikatori
AliasiFBXO16
Vanjski ID-jeviOMIM: 608519 MGI: 1354706 HomoloGene: 9273 GeneCards: FBXO16
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za FBXO16
Genomska lokacija za FBXO16
Bend8p21.1Početak28,348,287 bp[1]
Kraj28,490,278 bp[1]
Lokacija gena (miš)
Hromosom 14 (miš)
Hrom.Hromosom 14 (miš)[2]
Hromosom 14 (miš)
Genomska lokacija za FBXO16
Genomska lokacija za FBXO16
Bend14|14 D1Početak65,504,067 bp[2]
Kraj65,561,422 bp[2]
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_172366
NM_001258211

NM_015795
NM_001360381
NM_001360383

RefSeq (bjelančevina)

NP_001245140
NP_758954

NP_056610
NP_001347310
NP_001347312

Lokacija (UCSC)Chr 8: 28.35 – 28.49 MbChr 14: 65.5 – 65.56 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

F-kutijski protein 16 je protein koji je kod ljudi kodiran genom FBXO16.[5]

Aminokiselinska sekvenca

[uredi | uredi izvor]

Dužina polipeptidnog lanca je 292 aminokiseline, а molekulska težina 34.588 Da.[6]

1020304050
MMAFAPPKNTDGPKMQTKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWT
DSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSLYI
FSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYINFSPTPFEQG
IWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFR
SSSSLRKKNNSGEKALPPWRSSDKHPTDIIRFNYLDNRDPMETVQQGRRK
RNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSRRNPFPLCP

Funkcija

[uredi | uredi izvor]

Ovaj gen kodira člana proteina F-kutije, čije članove karakterizira približno 40 aminokiselinskih motiva, F-kutija. Proteini F-kutije čine jednu od četiri podjedinice kompleksa proteina ubikvitin-ligaza pod nazivom SCFs (SKP1-kulinska-F-kutija), koje funkcioniraju u sveprisutnosti ovisnoj o fosforilacijama. Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže WD-40 domene, Fbls koji sadrže ponavljanje bogato leucinom i Fbx koji sadrže bilo koje različite module interakcije protein-protein ili bez prepoznatljivih motiva. Protein kodiran ovim genom pripada klasi Fbx. Za ovaj gen pronađeno je više varijanti transkripta koje kodiraju različite izoforme.

Reference

[uredi | uredi izvor]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214050 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034532 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: F-box protein 16". Pristupljeno 13. 9. 2016.
  6. ^ "UniProt, Q8IX29" (jezik: engleski). Pristupljeno 17. 9. 2021.

Dopunska literatura

[uredi | uredi izvor]
  • Cheng H, Ma Y, Ni X, Jiang M, Guo L, Jin W, Xu W, Cao G, Ji C, Yin K, Gu S, Ma Y, Xie Y, Mao Y (2002). "cDNA cloning and expression analysis of a novel human F-box only protein". Mol. Cells. 14 (1): 56–9. PMID 12243353.
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FBXO16
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