DPYSL4

DPYSL4
Identifikatori
Aliasi	DPYSL4
Vanjski ID-jevi	OMIM: 608407 MGI: 1349764 HomoloGene: 4691 GeneCards: DPYSL4
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	132,205,759 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	138,682,620 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; • filamin binding;
Ćelijska komponenta	• citoplazma; • citosol;
Biološki proces	• neuron death; • neuron projection guidance; • nervous system development;
	Izvori:Amigo / QuickGO
Ortolozi
	10570
	26757
	ENSG00000151640
	ENSMUSG00000025478
	O14531
	O35098
	NM_006426
	NM_011993
	NP_006417
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dihidropirimidinazi srodni protein 4 je enzim koji je kod ljudi kodiran genom DPYSL4.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 572 aminokiseline, а molekulska težina 61.878.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSFQGKKSIP	RITSDRLLIR	GGRIVNDDQS	FYADVHVEDG	LIKQIGENLI
VPGGIKTIDA	HGLMVLPGGV	DVHTRLQMPV	LGMTPADDFC	QGTKAALAGG
TTMILDHVFP	DTGVSLLAAY	EQWRERADSA	ACCDYSLHVD	ITRWHESIKE
ELEALVKEKG	VNSFLVFMAY	KDRCQCSDSQ	MYEIFSIIRD	LGALAQVHAE
NGDIVEEEQK	RLLELGITGP	EGHVLSHPEE	VEAEAVYRAV	TIAKQANCPL
YVTKVMSKGA	ADAIAQAKRR	GVVVFGEPIT	ASLGTDGSHY	WSKNWAKAAA
FVTSPPVNPD	PTTADHLTCL	LSSGDLQVTG	SAHCTFTTAQ	KAVGKDNFAL
IPEGTNGIEE	RMSMVWEKCV	ASGKMDENEF	VAVTSTNAAK	IFNFYPRKGR
VAVGSDADLV	IWNPKATKII	SAKTHNLNVE	YNIFEGVECR	GAPAVVISQG
RVALEDGKMF	VTPGAGRFVP	RKTFPDFVYK	RIKARNRLAE	IHGVPRGLYD
GPVHEVMVPA	KPGSGAPARA	SCPGKISVPP	VRNLHQSGFS	LSGSQADDHI
ARRTAQKIMA	PPGGRSNITS	LS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151640 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025478 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ Byk T, Ozon S, Sobel A (Jul 1998). "The Ulip family phosphoproteins--common and specific properties". Eur J Biochem. 254 (1): 14–24. doi:10.1046/j.1432-1327.1998.2540014.x. PMID 9652388.
^ "Entrez Gene: DPYSL4 dihydropyrimidinase-like 4".
^ "UniProt, O14531". Pristupljeno 1. 9. 2021.

Dopunska literatura

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Inatome R, Tsujimura T, Hitomi T, et al. (2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J. Biol. Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
Honnorat J, Byk T, Kusters I, et al. (2000). "Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes". Eur. J. Neurosci. 11 (12): 4226–32. doi:10.1046/j.1460-9568.1999.00864.x. PMID 10594648. S2CID 11898553.

Vanjski linkovi

O14531

Kategorije

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151640 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025478 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[pmid9652388-6] Byk T, Ozon S, Sobel A (Jul 1998). "The Ulip family phosphoproteins--common and specific properties". Eur J Biochem. 254 (1): 14–24. doi:10.1046/j.1432-1327.1998.2540014.x. PMID 9652388.

[entrez-7] "Entrez Gene: DPYSL4 dihydropyrimidinase-like 4".

[UniProt-8] "UniProt, O14531". Pristupljeno 1. 9. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak

DPYSL4

Aminokiselinska sekvenca

Reference

Dopunska literatura

Vanjski linkovi

Suggest as cover photo

Thank you for helping!

Install Wikiwand

Don't forget to rate us

Tell your friends about Wikiwand!

Enjoying Wikiwand?

Tell your friends and spread the love:

Your preferred languages

All languages

Follow Us

Don't forget to rate us

Our magic isn't perfect

Thank you for helping!

Oh no, there's been an error