AZI2
5-azacitidin-inducirani protein 2 jest protein koji je kod ljudi kodiran genom AZI2 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 392 aminokiseline, а molekulska težina 44.935 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MDALVEDDIC | ILNHEKAHKR | DTVTPVSIYS | GDESVASHFA | LVTAYEDIKK | ||||
RLKDSEKENS | LLKKRIRFLE | EKLIARFEEE | TSSVGREQVN | KAYHAYREVC | ||||
IDRDNLKSKL | DKMNKDNSES | LKVLNEQLQS | KEVELLQLRT | EVETQQVMRN | ||||
LNPPSSNWEV | EKLSCDLKIH | GLEQELELMR | KECSDLKIEL | QKAKQTDPYQ | ||||
EDNLKSRDLQ | KLSISSDNMQ | HAYWELKREM | SNLHLVTQVQ | AELLRKLKTS | ||||
TAIKKACAPV | GCSEDLGRDS | TKLHLMNFTA | TYTRHPPLLP | NGKALCHTTS | ||||
SPLPGDVKVL | SEKAILQSWT | DNERSIPNDG | TCFQEHSSYG | RNSLEDNSWV | ||||
FPSPPKSSET | AFGETKTKTL | PLPNLPPLHY | LDQHNQNCLY | KN |
Funkcija
[uredi | uredi izvor]AZI2, ili NAP1, doprinosi aktivaciji NFKB (vidi MIM 164011) zavisne ekspresije gena, aktiviranjem IKK-vezanih kinaza, kao što je NAK (TBK1; MIM 604834) (Fujita et al., 2003; prema OMIM-u)[6]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
- ^ a b "Entrez Gene: AZI2 5-azacytidine induced 2".
- ^ "UniProt, Q9H6S1" (jezik: engleski). Pristupljeno 1. 11. 2021.
Dopunska literatura
[uredi | uredi izvor]- Funami K, Sasai M, Ohba Y, et al. (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi:10.4049/jimmunol.179.10.6867. PMID 17982077.
- Sasai M, Shingai M, Funami K, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi:10.4049/jimmunol.177.12.8676. PMID 17142768.
- Sasai M, Oshiumi H, Matsumoto M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi:10.4049/jimmunol.174.1.27. PMID 15611223.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vanjski linkovi
[uredi | uredi izvor]- Lokacija ljudskog genoma AZI2 i stranica sa detaljima o genu AZI2 u UCSC Genome Browseru.
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