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Angiopoetin |
- Agonisti: Angiopoetin 1
- Angiopoetin 4
- Antagonisti: Angiopoetin 2
- Angiopoetin 3
- Inhibitori kinaze: Altiratinib
- CE-245677
- Rebastinib
- Antitijela: Evinacumab (protiv angiopoetina 3)
- Nesvacumab (protiv angiopoetina 2)
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CNTF |
- Agonist: Agzokin
- CNTF
- Dapiclermin
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EGF (ErbB) | EGF (ErbB1/HER1) |
- Agonisti: Amfiregulin
- EGF (urogastron)
- Epigen* Epiregulin
- HB-EGF
- Murodermin
- Nepidermin
- TGFα
- Inhibitori kinaze: Afatinib
- Agerafenib
- Brigatinib
- Canertinib
- Dacomitinib
- Erlotinib
- Gefitinib
- Grandinin
- Icotinib
- Lapatinib
- Neratinib
- Osimertinib
- Vandetanib
- WHI-P 154
- Antitijela: Cetuksimab
- Depatuksizumab
- Depatuksizumab mafodotin
- Futuksimab
- Imgatuzumab
- Matuzumab
- Necitumumab
- Nimotuzumab
- Panitumumab
- Zalutumumab
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ErbB2/HER2 |
- Agonisti: Nepoznati/nema
- Antitijela: Ertumaksomab
- Pertuzumab
- Trastuzumab
- Trastuzumab-derukstekan
- Trastuzumab-duokarmazin
- Trastuzumab-emtanzin
- Inhibitori kinaze: Afatinib
- Lapatinib
- Mubritinib
- Tucatinib
|
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ErbB3/HER3 |
- Agonisti: Neuregulini (heregulini) (1, 2, 6 (neuroglikan C))
- Antitijela: Duligotumab
- Patritumab
- Seribantumab
|
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ErbB4/HER4 |
- Agonisti: Betacelulin
- Epigen
- HHB-EGF
- Neuregulini (heregulini) (1, 2, 3, 4, 5 (tomoregulin, TMEFF)
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FGF | FGFR1 |
- Agonisti: Erzofermin
- FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20)
- Repifermin
- Selperkatinib
- Trafermin
- Velafermin
|
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FGFR2 |
- Agonisti: Erzofermin
- FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)
- Palifermin
- Repifermin
- Selpercatinib
- Sprifermin
- Trafermin
- Antitijela: Aprutumab
- Aprutumab-iksadotin
- Inhibitori kinaze: Infigratinib
|
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FGFR3 |
- Agonisti: Ersofermin
- FGF (1, 2 (bFGF), 4, 8, 9, 18, 23)
- Selperkatinib
- Sprifermin
- Trafermin
- Antitijela: Burosumab (protiv FGF23)
|
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FGFR4 |
- Agonisti: Ersofermin
- FGF (1, 2 (bFGF), 4, 6, 8, 9, 19)
- Trafermin
|
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Neraspoređeni | |
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|
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HGF (c-Met) |
- Agonisti: Hepatocitni faktor rasta
- Potencijatori: Diheksa (PNB-0408)
- Inhibitori kinaze: Altiratinib
- AM7
- AMG-458
- Amuvatinib
- BMS-777607
- Foretinib
- Golvatinib
- INCB28060
- JNJ-38877605
- K252a
- Kabozantinib
- Kapmatinib
- MK-2461
- PF-04217903
- PF-2341066
- PHA-665752
- SU-11274
- Tivantinib
- Volitinib
- Antitijela: Emibetuzumab
- Fiklatuzumab
- Flanvotumab
- Onartuzumab
- Rilotumumab
- Telisotuzumab
- Telisotuzumab vedotin
|
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IGF | IGF-1 |
- Agonisti: des(1-3)IGF-1
- Somatomedin C
- IGF-1 LR3
- Somatomedin A
- Insulin
- Mekazermin
- Mekazermin-rinfabat
- Inhibitori kinaze BMS-754807
- Linsitinib
- NVP-ADW742
- NVP-AEW541
- OSl-906
- Antitijela: AVE-1642
- Ciksutumumab
- Dalotuzumab
- Figitumumab
- Ganitumab
- Robatumumab
- R1507
- Teprotumumab
- Ksentuzumab (protiv IGF-1 i IGF-2)
|
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IGF-2 | |
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Ostali |
- Vezujući proteini: IGFBP (1, 2, 3, 4, 5, 6, 7)
- Proizvodi razlaganja/izvedenice nepoznatog cilja: Glipromat (GPE, (1-3)IGF-1)
- Trofinetid
|
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|
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LNGF (p75NTR) |
- Agoniststi: BDNF
- BNN-20
- BNN-27
- Cenegermin
- DHEA
- DHEA-S
- NGF
- NT-3
- NT-4
- Antagonisti: ALE-0540
- Deksametazon
- EVT-901 (SAR-127963)
- Testosteron
- Antitijela: NGF: ABT-110 (PG110)
- ASP-6294
- Fazinumab
- Frunevetmab
- Fulranumab
- MEDI-578
- Ranevetmab
- Tanezumab
- Aptameri: protiv NGF: RBM-004
- Mamac-receptori: LEVI-04 (p75NTR-Fc)
|
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receptor PDGF |
- Agonists: Bekaplermin
- Trobocitni (A, B, C, D)
- Inhibitori kinaze: Agerafenib
- Avapritinib
- Aksitinib
- Krenolanib
- Imatinib
- Lenvatinib
- Masitinib
- Motesanib
- Nintedanib
- Pazopanib
- Radotinib
- Kvizartinib
- Ripretinib
- Sunitinib
- Sorafenib
- Toceranib
- Antitijela: Olaratumab
- Ramucirumab
- Tovetumab
|
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RET (GFL) | GFRα1 |
- Agonisti: GDNF
- Liatermin
- Inhibitori kinaze: Vandetanib
|
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GFRα2 | |
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GFRα3 |
- Agonisti: Artemin (ARTN)
- Inhibitori kinaze: Vandetanib
|
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GFRα4 |
- Agonisti: Perzefin (PSPN)
- Inhibitori kinaze: Vandetanib
|
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Unsorted | |
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|
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SCF (c-Kit) |
- Agonisti: Ancestim
- Faktor matične ćelije
- Inhibitori kinaze: Agerafenib
- Axitinib
- Dasatinib
- Imatinib
- Masitinib
- Nilotinib
- Pazopanib
- Kvizartinib
- Sorafenib
- Sunitinib
- Toceranib
|
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TGFβ | |
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Trk | TrkA |
- Agonists: Amitriptylin
- BNN-20
- BNN-27
- Cenegermin
- DHEA
- DHEA-S
- Gambogid-amid
- NGF
- Tavilermid
- Antagonisti: ALE-0540
- Deksametazon
- FX007
- Testosterone
- Negativni alosterni modulatori: VM-902A
- Inhibitori kinaze:Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrektinib
- GZ-389988
- K252a
- Larotrectinib
- Lestaurtinib
- Milciclib
- ONO-4474
- ONO-5390556
- PLX-7486
- Rebastinib
- SNA-120 (pegilatni K252a))
- Antitijela: protiv TrkA: GBR-900; protiv NGF: ABT-110 (PG110)
- ASP-6294
- Fasinumab
- Frunevetmab
- Fulranumab
- MEDI-578
- Ranevetmab
- Tanezumab
- Aptameri: protiv NGF: RBM-004
- Mamac-receptori: ReN-1820 (TrkAd5)
|
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TrkB |
- Agonists: 3,7-DHF
- 3,7,8,2'-THF
- 4'-DMA-7,8-DHF
- 7,3'-DHF
- 7,8-DHF
- 7,8,2'-THF
- 7,8,3'-THF
- Amitriptilin
- BDNF
- BNN-20
- Dezoksigedunin
- Deprenil
- Diosmetin
- DMAQ-B1
- HIOC
- LM22A-4
- N-Acetilserotonin
- NT-3
- NT-4
- Norvogonin (5,7,8-THF)
- R7
- R13
- TDP6
- Antagonisti: ANA-12
- Ciklotraksin B
- Gosipetin (3,5,7,8,3',4'-HHF)
- Ligandi: DHEA
- Inhibitori kinaze: Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrectinib
- GZ-389988
- K252a
- Larotrektinib
- Lestaurtinib
- ONO-4474
- ONO-5390556
- PLX-7486
|
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TrkC |
- Agonisti: BNN-20
- DHEA
- NT-3
- Inhibitori kinaze: Altiratinib
- AZD-6918
- CE-245677
- CH-7057288
- DS-6051
- Entrectinib
- GZ-389988
- K252a
- Larotrektinib
- Lestaurtinib
- ONO-4474
- ONO-5390556
- PLX-7486
|
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|
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VEGF |
- Agonisti: PGF
- Ripretinib
- Telbermin
- VEGF (A, B, C, D (FIGF)
- Alosterni modulatori: Ciklotraksin B
- Inhibiztori kinaze: Agerafenib
- Altiratinib
- Aksitinib
- Kabozantinib
- Cediranib
- Lapatinib
- Lenvatinib
- Motesanib
- Nintedanib
- Pazopanib
- Pegaptanib
- Rebastinib
- Regorafenib
- Semaxanib
- Sorafenib
- Sunitinib
- Tokeranib
- Tivozanib
- Vandetanib
- WHI-P 154
- Antitijela: Alacizumab-pegol
- Bevacizumab
- Icrucumab
- Ramucirumab
- Ranibizumab
- Receptori raspada: Aflibercept
|
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Ostali |
- Dodatni faktori rasta: Adrenomedulin
- Faktor stimuliranja kolonija (vidi Ovdje)
- CTGF
- Efrini (A1, A2, A3, A4, A5, B1, B2, B3)
- Eritropoetin (vidi Ovdje)
- GPI; PGI, PHI, AMF)
- GMF
- HDGF
- Interleukini/T-ćelijski faktor rasta (vidi Ovdje)
- LIF
- MSP
- NEGF2
- MSF; PRG4
- Onkomodulin
- PACA)
- Plejotrophin
- Renalaza
- Trombopoetin (vidi Ovdje)
- Wnt-signalni proteini
- Dodatni modulatori receptora faktora rasta: Cerebrolizin (mješavina neurotrofina)
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