SNAPC4

SNAPC4
識別號
别名	SNAPC4；, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
外部ID	OMIM：602777 MGI：2443935 HomoloGene：2321 GeneCards：SNAPC4
基因位置（人类）
染色体	9號染色體
终止	136,400,176 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	26,270,665 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• DNA结合转录因子活性; • DNA结合; • sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞組分	• 细胞核; • 核质; • snRNA-activating protein complex;
生物學過程	• regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated; • snRNA transcription by RNA polymerase III; • transcription by RNA polymerase III; • regulation of transcription by RNA polymerase II; • snRNA transcription by RNA polymerase II; • 细胞分化; • snRNA transcription;
	Sources:Amigo / QuickGO
直系同源
	6621
	227644
	ENSG00000165684
	ENSMUSG00000036281
	Q5SXM2
	Q8BP86
	NM_003086; NM_001394201; NM_001394202; NM_001394203
	NM_001290419; NM_172339
	NP_003077
NP_001277348; NP_758842; NP_001393660; NP_001393661; NP_001393662;
	NP_001393663; NP_001393664; NP_001393665; NP_001393666; NP_001393667; NP_001393668
	維基數據
檢視/編輯人類	檢視/編輯小鼠

snRNA激活蛋白复合体第四亚基（英語：snRNA-activating protein complex subunit 4）是一个由人类基因 SNAPC4 编码的蛋白质^[5]^[6]。

相互作用

SNAPC4能与SNAPC1^[7]、POU2F1^[5]^[8]和SNAPC2^[5]^[7]相互作用。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 ^5.2 Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N. The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1. Mol Cell Biol. January 1998, 18 (1): 368–77. PMC 121507 . PMID 9418884. 引用错误：带有name属性“pmid9418884”的<ref>标签用不同内容定义了多次
^ Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa.
^ ^7.0 ^7.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.
^ Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. (Denmark). March 2002, 58 (Pt 3): 511–2. ISSN 0907-4449. PMID 11856838. doi:10.1107/S0907444901021461.

延伸阅读

Henry RW, Sadowski CL, Kobayashi R, Hernandez N. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. Nature. 1995, 374 (6523): 653–6. PMID 7715707. doi:10.1038/374653a0.
Ma B, Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. 2001, 276 (7): 5027–35. PMID 11056176. doi:10.1074/jbc.M009301200.
Hovde S, Brooks A, Strong K, Geiger JH. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. 2002, 58 (Pt 3): 511–2. PMID 11856838. doi:10.1107/S0907444901021461.
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hinkley CS; Hirsch HA; Gu L; et al. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. J. Biol. Chem. 2003, 278 (20): 18649–57. PMID 12621023. doi:10.1074/jbc.M204247200.
Ota T; Suzuki Y; Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Humphray SJ; Oliver K; Hunt AR; et al. DNA sequence and analysis of human chromosome 9. Nature. 2004, 429 (6990): 369–74. PMC 2734081 . PMID 15164053. doi:10.1038/nature02465.
Beausoleil SA; Jedrychowski M; Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gu L, Esselman WJ, Henry RW. Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC. J. Biol. Chem. 2005, 280 (30): 27697–704. PMID 15955816. doi:10.1074/jbc.M503206200.
Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW. The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III. J. Biol. Chem. 2007, 282 (38): 27887–96. PMID 17670747. doi:10.1074/jbc.M702269200.

分类

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165684 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000036281 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9418884-5] 5.0 ^5.1 ^5.2 Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N. The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1. Mol Cell Biol. January 1998, 18 (1): 368–77. PMC 121507 . PMID 9418884. 引用错误：带有name属性“pmid9418884”的<ref>标签用不同内容定义了多次

[entrez-6] Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa.

[pmid11056176-7] 7.0 ^7.1 Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.

[pmid11856838-8] Hovde, Stacy; Brooks Aimee, Strong Katie, Geiger James H. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Acta Crystallogr. D Biol. Crystallogr. (Denmark). March 2002, 58 (Pt 3): 511–2. ISSN 0907-4449. PMID 11856838. doi:10.1107/S0907444901021461.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

SNAPC4

相互作用

参考文献

延伸阅读

Suggest as cover photo

Thank you for helping!

Install Wikiwand

Don't forget to rate us

Tell your friends about Wikiwand!

Enjoying Wikiwand?

Tell your friends and spread the love:

Your preferred languages

All languages

Follow Us

Don't forget to rate us

Our magic isn't perfect

Thank you for helping!

Oh no, there's been an error