锌激活离子通道
| Zinc activated ligand-gated ion channel 锌激活配体门控离子通道 | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | ZACN; L2; LGICZ; LGICZ1; ZAC; ZAC1 | ||||||||||||
| 扩展标识 | 遗传学：610935 同源基因：52296 IUPHAR: ZAC ChEMBL: 1628479 GeneCards: ZACN Gene | ||||||||||||
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| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 353174 | n/a | |||||||||||
| Ensembl | ENSG00000186919 | n/a | |||||||||||
| UniProt | Q401N2 | n/a | |||||||||||
| mRNA序列 | NM_180990 | n/a | |||||||||||
| 蛋白序列 | NP_851321 | n/a | |||||||||||
| 基因位置 |
Chr 17: 74.07 – 74.08 Mb | n/a | |||||||||||
| PubMed查询 | [1] | n/a | |||||||||||
锌激活离子通道（英語：Zinc-activated ion channel，ZAC），是一种由人类基因ZACN 编码的蛋白质。ZAC属于阳离子渗透型配体门控离子通道中的半胱氨酸环超家族。ZAC的基因存在于人类和犬类中，但其直系同源体在鼠类中却未发现[1]。
ZAC的mRNA表达于前列腺、甲状腺、气管、肺、脑（包括成人和胎儿）、脊髓、骨骼肌、心脏、胎盘、胰腺、肝、肾和胃[1][2]。ZAC的内源性配体是Zn2+，但ZAC 也能自发性激活，其自发性激活的原因还未知[1]。
参考文献
[编辑]- ^ 1.0 1.1 1.2 Davies PA; Wang W; Hales TG; Kirkness EF. A novel class of ligand-gated ion channel is activated by Zn2+. J Biol. Chem. 2003, 278 (2): 712–7. PMID 12381728. doi:10.1074/jbc.M208814200.
- ^ Houtani T; Munemoto Y; Kase M; Sakuma S; Tsutsumi T; Sugimoto T. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. Biochem Biophys Res Commun. 2005, 335 (2): 227–85. PMID 16083862. doi:10.1016/j.bbrc.2005.07.079.
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