视黄酸诱导孤儿G蛋白偶联受体
| G蛋白偶联受体，家族C，第5组，成员A | |
|---|---|
| 識別 | |
| 符號 | GPRC5A |
| 替換符號 | RAIG1, RAI3 |
| Entrez | 9052 |
| HUGO | 9836 |
| OMIM | 604138 |
| RefSeq | NM_003979 |
| UniProt | Q8NFJ5 |
| 其他資料 | |
| 基因座 | 12 p13-p12.3 |
| G蛋白偶联受体，家族C，第5组，成员B | |
|---|---|
| 識別 | |
| 符號 | GPRC5B |
| 替換符號 | RAIG2 |
| Entrez | 51704 |
| HUGO | 13308 |
| OMIM | 605948 |
| RefSeq | NM_016235 |
| UniProt | Q9NZH0 |
| 其他資料 | |
| 基因座 | 16 p12 |
| G蛋白偶联受体，家族C，第5组，成员C | |
|---|---|
| 識別 | |
| 符號 | GPRC5C |
| 替換符號 | RAIG3 |
| Entrez | 55890 |
| HUGO | 13309 |
| OMIM | 605949 |
| RefSeq | NM_022036 |
| UniProt | Q9NQ84 |
| 其他資料 | |
| 基因座 | 17 q25 |
| G蛋白偶联受体，家族C，第5组，成员D | |
|---|---|
| 識別 | |
| 符號 | GPRC5D |
| Entrez | 55507 |
| HUGO | 13310 |
| OMIM | 607437 |
| RefSeq | NM_018654 |
| UniProt | Q9NZD1 |
| 其他資料 | |
| 基因座 | 12 p13.3 |
视黄酸诱导孤儿G蛋白偶联受体（英语：Retinoic Acid-Inducible orphan G-protein-coupled receptor），缩写为RAIG，是一组四个密切相关的G蛋白偶联受体，其表达由视黄酸诱导。[1][2][3][4]
这些蛋白质的确切功能尚未确定，但它们可能提供了视黄酸影响G蛋白信号转导级联的机制。此外，RAIG受体与卷曲类G蛋白偶联受体的成员相互作用，并似乎激活Wnt信号通路。[5]
参考资料
[编辑]- ^ Cheng Y, Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 1998, 273 (52): 35008–15. PMID 9857033. doi:10.1074/jbc.273.52.35008
.
- ^ Bräuner-Osborne H, Krogsgaard-Larsen P. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics. 2000, 65 (2): 121–8. PMID 10783259. doi:10.1006/geno.2000.6164.
- ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics. 2000, 67 (1): 8–18. PMID 10945465. doi:10.1006/geno.2000.6226.
- ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim. Biophys. Acta. 2001, 1518 (3): 237–48. PMID 11311935. doi:10.1016/s0167-4781(01)00197-x.
- ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X. Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling. Biochem. Biophys. Res. Commun. 2007, 358 (4): 968–75. PMC 2854581 . PMID 17521608. doi:10.1016/j.bbrc.2007.04.208.
外部链接
[编辑]- GPRC5 (RAIG) Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2023-12-10]. （原始内容存档于2016-03-03）.
- 醫學主題詞表（MeSH）：GPRC5A+protein,+human
- 醫學主題詞表（MeSH）：GPRC5B+protein,+human
- 醫學主題詞表（MeSH）：GPRC5C+protein,+human
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