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補體成分7

補體成分7
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名C7;, complement component 7, complement C7
外部IDOMIM217070 MGI88235 HomoloGene:489 GeneCardsC7
相關疾病
complement component 9 deficiency[1]
基因位置(人类
5號染色體
染色体5號染色體[2]
5號染色體
補體成分7的基因位置
補體成分7的基因位置
基因座5p13.1起始40,909,492 bp[2]
终止40,984,643 bp[2]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_000587

NM_001243837

蛋白序列

NP_000578

NP_001230766

基因位置​(UCSC)Chr 5: 40.91 – 40.98 MbChr 15: 5.02 – 5.09 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

補體成分C7(Complement component 7),即C7,在人體內是一個由C7基因編碼的、分子量為97kD血清糖蛋白。C7分子的主要作用是參與形成膜攻擊複合物(MAC)。在MAC形成過程中,在C5b-C6複合物形成後,C7分子會與之結合,隨後,C8C9分子再與C5b-C6-C7複合物結合,形成完整的MAC[6][7]:41-45

參見

[编辑]

參考

[编辑]
  1. ^ 與補體成分7相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000112936 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000079105 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Complement C7. NIH. [2018-04-24]. (原始内容存档于2018-05-09). 
  7. ^ 曹雪濤等. 醫學免疫學 第6版. 北京: 人民衛生出版社. 2013. ISBN 978-7-117-17101-4. 
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補體成分7
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