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蝶啶

蝶啶
Pteridine molecule
C=black, H=white, N=blue
Pteridine molecule
C=black, H=white, N=blue
IUPAC名
Pteridine[1]
识别
CAS号 91-18-9  checkY
PubChem 1043
ChemSpider 1014
SMILES
 
  • C1=CN=C2C(=N1)C=NC=N2
InChI
 
  • 1/C6H4N4/c1-2-9-6-5(8-1)3-7-4-10-6/h1-4H
InChIKey CPNGPNLZQNNVQM-UHFFFAOYAU
ChEBI 27601
KEGG C07581
性质
化学式 C6H4N4
摩尔质量 132.12 g·mol−1
熔点 139.5 °C(413 K)
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

喋啶(Pteridine)是一种芳香族杂环有机物,含有一个嘧啶环以及一个吡嗪环。喋啶是蝶呤核黄素生物合成的中间体[2]磺胺类药物作用机制就是与对氨基苯甲酸(PABA)竞争二氢叶酸合酶英语Dihydrofolate synthase的反应位点,进而阻止PABA与喋啶合成为二氢叶酸的反应[3]

参见

参考文献

  1. ^ International Union of Pure and Applied Chemistry. Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. 2014: 212. ISBN 978-0-85404-182-4. doi:10.1039/9781849733069. 
  2. ^ Kritsky, M. S; Telegina, T. A; Vechtomova, Y. L; Kolesnikov, M. P; Lyudnikova, T. A; Golub, O. A. Excited flavin and pterin coenzyme molecules in evolution. Biochemistry. Biokhimiia. 2010, 75 (10): 1200–16. PMID 21166638. S2CID 19455034. doi:10.1134/s0006297910100020. 
  3. ^ M. Madigan; et al. Brock Biology of Microorganisms 13th. Pearson Education. 2012: 797. ISBN 9780321735515 (英语). 
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蝶啶
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