氯噻嗪
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| 臨床資料 | |
|---|---|
| 商品名 | Diuril, others |
| 其他名稱 | 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682341 |
| 给药途径 | By mouth, IV |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 | |
| 藥物動力學數據 | |
| 生物利用度 | low |
| 药物代谢 | Nil |
| 生物半衰期 | 45 to 120 minutes |
| 排泄途徑 | Renal |
| 识别信息 | |
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| CAS号 | 58-94-6  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.368 |
| 化学信息 | |
| 化学式 | C7H6ClN3O4S2 |
| 摩尔质量 | 295.71 g·mol−1 |
| 3D模型（JSmol） | |
| 熔点 | 342.5—343 °C（648.5—649.4 °F） |
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氯噻嗪（化学式：C7H6ClN3O4S2）是一种有机化合物，可用作利尿劑和抗高血压药。[1][2]
它于1956年获得专利，并于1958年被批准用于医疗。[3]它是世界卫生组织基本药物标准清单上的药物。[4]
参考文献
[编辑]- ^ Ernst ME, Grimm J, Richard H. Thiazide diuretics: 50 years and beyond.. Current Hypertension Reviews. November 2008, 4 (4): 256–65. doi:10.2174/157340208786241264.
- ^ Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Review of Cardiovascular Therapy. June 2010, 8 (6): 793–802. PMC 2904515
. PMID 20528637. doi:10.1586/erc.10.27.
- ^ Fischer J, Ganellin CR. Analogue-based Drug Discovery. John Wiley & Sons. 2006: 456. ISBN 9783527607495 （英语）.
- ^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02.
参见
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