昔康
昔康(英語：Oxicam)是一類非類固醇抗發炎藥(NSAIDS)，其可和血漿蛋白緊密結合。[1]大多數的昔康類藥物会不具選擇性地抑制環氧合酶，唯一的例外是美洛昔康，其稍微偏好抑制COX-2(10:1)，然而，此在低劑量下才有臨床上的重要性。[2]
昔康的種類包括：
- 安吡昔康
- 屈昔康
- 氯諾昔康
- 美洛昔康
- 吡羅昔康
- 替諾昔康
化學結構
[编辑]昔康類化合物的物理化學性質可因環境有所不同[3]，相對於其他非類固醇抗發炎藥，昔康類不是羧酸，其会異構互變並且具有多重的互變異構體(酮-烯醇互变异构)，下有附圖以吡羅昔康為例：[4]
藥物副作用
[编辑]昔康類藥物的使用被認為與多形性紅斑、史蒂芬斯－強森症候群和毒性表皮壞死溶解症有關，此關聯為昔康類藥物不會被普遍地作為主要處方用藥原因之一。
參考資料
[编辑]- ^ Olkkola KT, Brunetto AV, Mattila MJ. Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents. Clinical Pharmacokinetics. 1994, 26 (2): 107–20. PMID 8162655. doi:10.2165/00003088-199426020-00004.
- ^ Mutschler, Ernst; Gerd Geisslinger; Heyo K. Kroemer; Monika Schäfer-Korting. Arzneimittelwirkungen 8. Stuttgart: Wissenschaftliche Verlagsgesellschaft. 2001: 233. ISBN 3-8047-1763-2 （德语）.
- ^ Banerjee R, Chakraborty H, Sarkar M. Photophysical studies of oxicam group of NSAIDs: piroxicam, meloxicam and tenoxicam. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2003, 59 (6): 1213–22. Bibcode:2003AcSpA..59.1213B. PMID 12659890. doi:10.1016/S1386-1425(02)00300-1.
- ^ Ivanova D, Deneva V, Nedeltcheva D, Kamounah FS, Gergov G, Hansen PE, Kawauchi S, Antonov L. Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study. RSC Advances. 2015, 5 (40): 31852–31860. doi:10.1039/c5ra03653d
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