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逆转录酶抑制剂

核苷类逆转录酶抑制剂(英語:Nucleoside Reverse Transcriptase Inhibitors,简称NRTIs),是合成HIVDNA逆转录底物脱氧核苷酸的类似物,在体内转化成活性的三磷酸核苷衍生物,与天然的三磷酸脱氧核苷竞争性与HIV逆转录酶(RT)结合,抑制RT的作用,阻碍前病毒的合成。

已上市的NRTIs药物有:齐多夫定去羟肌苷、扎西他滨、司坦夫定、拉米夫定阿巴卡韦等。

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逆转录酶抑制剂
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