信号识别颗粒RNA
| 信号识别颗粒RNA | |||||||||||||||||||||||||
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| 識別號 | |||||||||||||||||||||||||
| 别名 | RN7SL1；, 7L1a, 7SL, RN7SL, RNSRP1, Signal recognition particle RNA, RNA, 7SL, cytoplasmic 1, RNA component of signal recognition particle 7SL1 | ||||||||||||||||||||||||
| 外部ID | OMIM：612177 GeneCards：RN7SL1 | ||||||||||||||||||||||||
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| 直系同源 | |||||||||||||||||||||||||
| 物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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| 蛋白序列 |
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| 基因位置（UCSC） | Chr 14: 49.59 – 49.59 Mb | 无数据 | |||||||||||||||||||||||
| PubMed查找 | [2] | 无数据 | |||||||||||||||||||||||
| 維基數據 | |||||||||||||||||||||||||
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信号识别颗粒RNA（Signal recognition particle RNA，簡稱SRP RNA，又稱7SL RNA）是生物細胞信號識別顆粒中的RNA，在三域生物中皆有，信号识别颗粒（SRP）由RNA與蛋白質組成，可與核糖體轉譯中多肽上的信號肽結合，暫停轉譯，並與細胞內質網（真核生物）或細胞膜（原核生物）的訊息確認顆粒受體結合，將核糖體轉移至這些膜結構上[3][4]，過去認為SRP RNA在SRP中僅有維持結構的功能，後續研究發現SRP RNA可協助SRP和受體的結合，並在結合後催化兩個三磷酸鳥苷（GTP）分子的水解，促使SRP自訊息確認顆粒受體與核糖體脫離，使核糖體繼續多肽的轉譯[5][6]。
真核生物的SRP由長約300nt的7SL RNA和6個蛋白質（SRP9、SRP14、SRP19、SRP54、SRP68與SRP72）組成，古菌的SRP由7SL RNA和2個蛋白質組成[7]，真細菌的SRP則由4.5S RNA和Fth蛋白組成[8]。SRP RNA最早在1970年在病毒中被發現[9]。真核生物的SRP RNA與tRNA與5S 核糖體RNA一樣是由RNA聚合酶III轉錄[10]。
除組成SRP之外，有研究發現許多反轉錄病毒顆粒中含有未與SRP蛋白結合的SRP RNA等宿主細胞的RNA，惟其功能尚不明[6]。另外也有研究在成纖維細胞與癌細胞互動後釋放的外排體中[11]，以及人類和小鼠的紅血球細胞中發現未與SRP蛋白結合的SRP RNA[12]。
人類基因組中占比超過10%、最常見的短散在核元件（SINE）Alu元件可能是自SRP RNA中間一段序列刪除後衍生而來[13]。
參考文獻
[编辑]
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000276168 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ulbrandt ND, Newitt JA, Bernstein HD. The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. Cell. 1997, 88 (2): 187–196. PMID 9008159. doi:10.1016/S0092-8674(00)81839-5.
- ^ Zwieb C, Eichler J. Getting on target: the archaeal signal recognition particle. Archaea. 2002, 1 (1): 27–34. PMC 2685543
. PMID 15803656. doi:10.1155/2002/729649.
- ^ Shan SO, Walter P. Co-translational protein targeting by the signal recognition particle. FEBS Letters. February 2005, 579 (4): 921–926. PMID 15680975. doi:10.1016/j.febslet.2004.11.049.
- ^ 6.0 6.1 Telesnitsky A, Wolin SL. The Host RNAs in Retroviral Particles.. Viruses. 2016, 8 (8). PMC 4997597 . PMID 27548206. doi:10.3390/v8080235.
- ^ Rosenblad MA, Larsen N, Samuelsson T, Zwieb C. Kinship in the SRP RNA family. RNA Biology. 2009, 6 (5): 508–516. PMID 19838050. doi:10.4161/rna.6.5.9753.
- ^ Regalia M, Rosenblad MA, Samuelsson T. Prediction of signal recognition particle RNA genes. Nucleic Acids Research. 2002, 30 (15): 3368–3377. PMC 137091 . PMID 12140321. doi:10.1093/nar/gkf468.
- ^ Bishop JM, Levinson WE, Sullivan D, Fanshier L, Quintrell N, Jackson J. The low molecular weight RNAs of Rous sarcoma virus. II. The 7 S RNA. Virology. 1970, 42 (4): 927–937. PMID 4321311. doi:10.1016/0042-6822(70)90341-7.
- ^ Dieci G, Fiorino G, Castelnuovo M, Teichmann M, Pagano A. The expanding RNA polymerase III transcriptome.. Trends in Genetics. 2007, 23 (12): 614–622. PMID 17977614. doi:10.1016/j.tig.2007.09.001. hdl:11381/1706964.
- ^ Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC; et al. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.. Cell. 2017, 170 (2): 352–366.e13. PMC 6611169 . PMID 28709002. doi:10.1016/j.cell.2017.06.031.
- ^ Talhouarne GJS, Gall JG. 7SL RNA in vertebrate red blood cells.. RNA. 2018, 24 (7): 908–914. PMC 6004055 . PMID 29686135. doi:10.1261/rna.065474.117.
- ^ Ullu E, Tschudi C. Alu sequences are processed 7SL RNA genes. Nature. 1984, 312 (5990): 171–172. PMID 6209580. doi:10.1038/312171a0.
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