For faster navigation, this Iframe is preloading the Wikiwand page for 代謝工程學.

代謝工程學

细胞代谢可以为工业应用而优化
大肠杆菌基因添加到专性甲基营养细菌上

代謝工程學是指利用基因工程或是分子生物學技術,將生體內之代謝途径改變,通常改變生體內化學反應。它來自於发酵学。代謝工程技術目前以微生物利用為主,改變工業微生物之代謝路徑,生產所需要的化學物質,如抗生素

代谢工程(Metabolic engineering)又称途径工程,一般定义为通过某些特定生化反应的修饰来定向改善细胞的特性,或是利用重组DNA技术来创造新的化合物

这一概念由美国学者Bailey J E于1991年首先提出[1]。其将代谢工程定义为:用重组DNA技术来操纵细胞的酶运输和调节功能从而改进细胞的活性。Stephanopouls等认为,代谢工程是一种提高菌体生物量或代谢物产量的理性化方法。Cameron等的定义则精炼一些,即用重组DNA技术有目的地改造中间代谢。

参考文献

[编辑]

引用

[编辑]
  1. ^ Bailey J E. Science.1991 ,225(12): 1668

来源

[编辑]
  • Bailey J E. Science.1991 ,225(12): 1668
  • Stephanopoulos, G. N., Aristidou, A. A., Nielsen, J. (1998). "Metabolic Engineering: Principles and Methodologies". San Diego: Academic Press.
  • Domach, M. M. (2004). Introduction to biomedical engineering. Upper Saddle River: Pearson Prentice Hall.

参见

[编辑]
{{bottomLinkPreText}} {{bottomLinkText}}
代謝工程學
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install
{{::$root.activation.text}}

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!


Your input will affect cover photo selection, along with input from other users.

X

Get ready for Wikiwand 2.0 🎉! the new version arrives on September 1st! Don't want to wait?