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人绒毛膜促性腺激素

绒毛膜促性腺激素,α肽链
識別
符號 CGA
替換符號 FSHA, GPHa, GPHA1, HCG, LHA, TSHA
Entrez 1081
HUGO 1885
OMIM 118850
RefSeq NM_000735
UniProt P01215
其他資料
基因座 6 q14-q21
绒毛膜促性腺激素,β肽链
識別
符號 CGB
替換符號 CGB3
Entrez 1082
HUGO 1886
OMIM 118860
RefSeq NM_000737
UniProt P01233
其他資料
基因座 19 q13.3

人绒毛膜促性腺激素(英語:Human chorionic gonadotropin,简写为hCG)是一种糖蛋白激素,由胎盤滋胚層細胞分泌,主要功能是刺激黃體,有利於雌激素黃體酮持續分泌,以促進子宮蛻膜形成,使胎盤生長成熟。胚胎一旦著床後,滋胚層細胞就會開始分泌hCG,所以可以透過血中或尿中hCG值來判斷妊娠。

由244个氨基酸残基组成,分子量36.7kDa,大小7.5×3.5×3纳米。为异源二聚体,其α亚基与促黄体素(LH)、促滤泡素(FSH)和促甲狀腺激素(TSH)的α亚基相同,其β亚基则不同。α亚基含92个氨基酸残基,β亚基含145个氨基酸残基。

女性体内hCG的合成在受孕后显著提高,血浆和尿液中hCG的存在是怀孕的最早期信号之一,用于妊娠检测

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人绒毛膜促性腺激素
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