INF2
| INF，FH2及WH2领域包括 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 标识 | |||||||||||||
| 代号 | INF2; C14orf151; C14orf173; CMTDIE; FSGS5; pp9484 | ||||||||||||
| 扩展标识 | 遗传学：610982 鼠基因：1917685 同源基因：82406 GeneCards: INF2 Gene | ||||||||||||
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| RNA表达模式 | |||||||||||||
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| 更多表达数据 | |||||||||||||
| 直系同源体 | |||||||||||||
| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 64423 | 70435 | |||||||||||
| Ensembl | ENSG00000203485 | ENSMUSG00000037679 | |||||||||||
| UniProt | Q27J81 | Q0GNC1 | |||||||||||
| mRNA序列 | NM_001031714 | NM_198411 | |||||||||||
| 蛋白序列 | NP_001026884 | NP_940803 | |||||||||||
| 基因位置 |
Chr 14: 105.16 – 105.19 Mb |
Chr 12: 112.59 – 112.62 Mb | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
临床意义
"逆霍明2"与局灶节段性肾小球硬化症有所相关联。[3]
注释
- ^ Chhabra ES, Higgs HN. INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization. J Biol Chem. Sep 2006, 281 (36): 26754–67. PMID 16818491. doi:10.1074/jbc.M604666200.
- ^ Entrez Gene: C14orf173 chromosome 14 open reading frame 173.
- ^ Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nature Genetics. Jan 2010, 42 (1): 72–6. PMC 2980844
. PMID 20023659. doi:10.1038/ng.505.
延伸阅读
- Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Bindschadler M, McGrath JL. Formin' new ideas about actin filament generation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (41): 14685–6. PMC 522045 . PMID 15466701. doi:10.1073/pnas.0406317101.
- Fu GK, Wang JT, Yang J; et al. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Genomics. 2005, 84 (1): 205–10. PMID 15203218. doi:10.1016/j.ygeno.2004.01.011.
- Gevaert K, Goethals M, Martens L; et al. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. 2004, 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Venter JC, Adams MD, Myers EW; et al. The sequence of the human genome. Science. 2001, 291 (5507): 1304–51. PMID 11181995. doi:10.1126/science.1058040.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
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