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转化医学

转化医学(英语:translational medicine,中国大陆常译转化医学,台湾常译转译医学)是指将基础医学的研究,能够直接和临床治疗上连结的一个新的思维。最早由美国国家卫生研究院(National Institute of Health, NIH) 之爱力思·乐霍尼 (Elias A. Zerhouni) 院长,在美国医学会期刊(JAMA)发表了一篇“US Biomedical Research-Basic, Translational, and Clinical Sciences” 之文章,提到了转化医学这个新的思维。[1]

在过去,基础医学和药物开发以及临床上的治疗是分开的三个领域。但是随着生物科技技术发展,让研究标的得以大规模分析,并且借由生物资讯的统计分析,让这三个分开的领域得以快速连结。这也是所谓转化医学的内涵。让以往疾病研究上的分子致病机转研究的成果,能用直接运用于临床治疗。

转化医学研究之过程方式

转化医学结合基础的医学研究,结合到病床的临床诊治。在过程上可以大致分为

  1. 研究疾病的病理机制。
  2. 临床病人所展现的疾病特征,疾病所出现的生物标记,以及致病的分子途径。
  3. 由第一,二点的发现,来进行有系统的研究与分析。并且发展新的诊断治疗方式,以及特定药物的开发。
  4. 所获得的诊断治疗方式和特定药物,来进行个体化(personalized) 的治疗。[2]

期刊

参考文献

  1. ^ 存档副本. [2009-07-16]. (原始内容存档于2009-02-15). 
  2. ^ 國家衛生研究院(臺灣)電子報. [2009-07-16]. (原始内容存档于2014-04-13). 

外部链接

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转化医学
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