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儿童多系统炎症综合征

儿童多系统炎症综合征(英语:multisystem inflammatory syndrome in children,MIS-C[1][2][3],或称小儿多系统发炎症候群(英语:paediatric inflammatory multisystem syndrome,PIMS,PIMS-Ts[4][5]是接触2型新冠病毒后出现的一种罕见的全身性疾病,症状包括持续发烧和极端炎症;其为2020年定义的新病症。

美国疾病控制与预防中心的病例定义如下:小于21岁、发烧>38.0°C 超过24小时、检验证明发炎反应(CRP,ESR,fibrinogen,procalcitonin,d-dimer,ferritin,LDH,IL-6,高嗜中性球并低淋巴球及低白蛋白)、至少两个器官受损(心,肾,呼吸,血液,胃肠,皮肤,神经)、排除其他可解释的疾病、SARS-CoV-2感染。[6]

主发在五岁以下儿童,主要症状为全身性发炎发烧器官衰竭,其他可能症状包括结膜炎皮疹腹泻,病情可能部分或完全符合川崎病的诊断条件。验室的诊断条件包括纤维蛋白原浓度异常、白蛋白和淋巴细胞计数低 、以及C反应蛋白、D-二聚体和铁蛋白增高。[7][8][9][10][11]

2020年在纽约报告了100例,法国125例,同时英国等地也有确诊。因于发生时间点与严重特殊传染性肺炎疫情重合,有人怀疑两者相关,但未得到证实。虽然患者可能也验出严重急性呼吸系统综合症冠状病毒2型,但这不足以证明两者有关,必须先排除验出的所有其他微生物。

世界卫生组织的儿童和青少年多系统炎症综合征初步病例定义

参考资料

  1. ^ 存档副本. [2022-06-08]. (原始内容存档于2022-08-15). 
  2. ^ 存档副本. [2021-06-26]. (原始内容存档于2021-06-26). 
  3. ^ 存档副本. [2021-06-26]. (原始内容存档于2021-06-26). 
  4. ^ 存档副本. [2022-06-08]. (原始内容存档于2022-08-10). 
  5. ^ Pediatric Inflammatory Multisystem Syndrome (PIMS): What Parents Should Know. Children's Hospital Los Angeles. 8 May 2020 [14 May 2020]. (原始内容存档于2020-05-18) (英语). 
  6. ^ 存档副本. [2021-06-26]. (原始内容存档于2021-06-28). 
  7. ^ McNamara, Audrey. 15 states now investigating child illness possibly linked to coronavirus, Cuomo says. www.cbsnews.com. 13 May 2020 [14 May 2020]. (原始内容存档于2020-12-16). 
  8. ^ C, Manon. Coronavirus: 125 children have been reportedly suffering from the Kawasaki disease these past few weeks. www.sortiraparis.com. [14 May 2020]. (原始内容存档于2020-05-13) (英语). 
  9. ^ Shelley Riphagen; Xabier Gomez; Carmen Gonzalez-Martinez; Nick Wilkinson; Paraskevi Theocharis, Hyperinflammatory shock in children during COVID-19 pandemic, The Lancet, 7 May 2020 [2020-05-14], doi:10.1016/S0140-6736(20)31094-1, (原始内容存档于2021-02-16) 
  10. ^ Pam Belluck, A New Coronavirus Threat to Children, New York Times, 6 May 2020 [2020-05-14], (原始内容存档于2020-05-09) 
  11. ^ Edwards, Erika. At least 85 kids across U.S.. NBC News. 7 May 2020 [10 May 2020]. (原始内容存档于2021-03-12) (英语). 
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儿童多系统炎症综合征
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