优降宁
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| 临床资料 | |
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| MedlinePlus | a682088 |
| ATC码 | |
| 识别信息 | |
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| CAS号 | 555-57-7  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.008.275 |
| 化学信息 | |
| 化学式 | C11H13N |
| 摩尔质量 | 159.23 g·mol−1 |
| 3D模型（JSmol） | |
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优降宁是不可逆、选择性的单胺氧化酶抑制剂（MAO-A和MAO-B的IC50分别为11.52 nM和8.20 nM）。[1][2]1963年，它由雅培以抗高血压药的形式进入美国及英国市场，商品名Eutonyl。同样于1960年代进入市场的单胺氧化酶抑制剂还有尼亚拉胺、异卡波肼、苯乙肼、反苯环丙胺。[3]:146[4]:60[5][6]优降宁于2007年被停用。[7]它除了作为单胺氧化酶抑制剂，也会与单胺氧化酶的别构中心I2咪唑啉受体结合。[8]
参见
[编辑]- 氯吉兰
- 雷沙吉兰
- 司来吉兰
参考资料
[编辑]- ^ Fisar Z, Hroudová J, Raboch J. Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.. Neuro Endocrinol Lett. 2010, 31 (5): 645–56. PMID 21200377.
- ^ Murphy DL, Karoum F, Pickar D, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline). MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement 52. 1998: 39–48. ISBN 978-3-211-83037-6. PMID 9564606. doi:10.1007/978-3-7091-6499-0_5.
|journal=被忽略 (帮助) - ^ Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685
- ^ William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676
- ^ Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) （页面存档备份，存于互联网档案馆） JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.
- ^ Eutonyl and MAO inhibitors. Drug and Therapeutics Bulletin. 15 November 1963, 1 (15): 59–60 [2024-02-18]. ISSN 1755-5248. S2CID 220162992. doi:10.1136/dtb.1.15.59. （原始内容存档于2024-06-06） （英语）.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
- ^ W. Steven Pray. Interactions Between Nonprescription Products and Psychotropic Medications. www.medscape.com. 2007 [2024-02-18]. （原始内容存档于2021-05-15）.
- ^ Critical Reviews in Neurobiology. CRC Press. 1995: 43.
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