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Kabazitaksel.
Kabazitaksel, doğal bir taksoidin yarı sentetik bir türevidir.[1] Bir mikrotübül inhibitörü ve kanser tedavisi olarak onaylanacak dördüncü taksandır.
Kabazitaksel, Sanofi-Aventis tarafından geliştirilmiş ve Haziran 2010'da ABD Gıda ve İlaç Dairesi (FDA) tarafından hormona dirençli prostat kanserinin tedavisi için onaylanmıştır.[2] Jenerik ilaç olarak mevcuttur.[3][4]
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SPler/MIler (M fazı) | Mikrotübül birleşimini engelleyenler | |
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Mikrotübül dağılmasını engelleyenler | |
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DNA replikasyonu inhibitörleri | DNA prekürsörleri/ antimetabolitler (S fazı) | Folik asit | Dihidrofolat redüktaz inhibitörü(Aminopterin · Metotreksat# · Pemetrekset · Pralatreksat ·) Timidilat sentaz inhibitörü(Pemetrekset · Raltitreksed) |
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Pürin | Adenozin deaminaz inhibitörü( Pentostatin) · Halogenlenmiş/ribonükleotid redüktaz inhibitörüler (Kladribin · Klofarabin · Fludarabin) · Nelarabin · Tiyopürin ( Merkaptopürin# · Tiyoguanin #) |
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Pirimidin | Timidilat sentaz inhibitörü (Kapesitabin# · Karmofur · Doksifluridin · Floksuridin · Fluorourasil# · Tegafur (+gimerasil/oterasil)) · DNA polimeraz inhibitörü (Sitarabin# (+daunorubisin) · Ribonükleotid redüktaz inhibitörü (Gemisitabin#) · Hipometilleyici ajan ( Azasitidin · Desitabin) |
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Deoksiribonükleotit | |
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Topoizomeraz inhibitörleri (S fazı) | I | Kamptoteka (Belotekan · Kamptotesin · Kositikan † · Etirinotekan pegol † · Eksatekan · Gimatekan · İrinotekan # · Lurtotekan ‡ · Rubitekan ‡ · Silatekan § · Topotekan) |
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II | |
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II+Enterkalasyon | Antrasiklinler (Aklarubisin · Amrubicin † · Daunorubisin# (+sitarabin) · Doksorubisin# · Epirubisin · İdarubisin · Pirarubisin · Valrubicin · Zorubisin) · Antrasenedionlar ( Mitoksantron · Losoksantron · Piksantron) · Amsakrin · Bisantren · Krisnatol · Menogaril § |
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Fotosensitize ediciler/PDT | Aminolevulinik asit · Efaproksiral · Metil aminolevulinat · Porfirin türevleri (Porfirin sodyum · Talaporfin · Temoporfin · Verteporfin) |
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Diğer | Enzim İnhibitörleri | FI ( Tipifarnib § ) · CDK inhibitörleri ( Abemasiklib · Alvosidib † · Palbosiklib · Ribosiklib · Selisiklib † ) · PrI ( Bortezomib · Karfilzomib · Oprozomib · Iksazomib ) · PhI ( Anagrelid ) · IMPDI ( Tiyazofurin § ) · LI ( Masoprocol ) · PARP inhibitor ( Niraparib +abiraterone acetate ) · Olaparib · Rucaparib ) · HDAC ( Belinostat · Entinostat · Panobinostat · Romidepsin · Vorinostat ) · PIKI (Pi3K) ( Alpelisib · Copanlisib · Duvelisib · Idelalisib · Umbralisib ‡ ) |
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Reseptör antagonistleri | |
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Diğer/gruplandırılmamış | Adagrasib · Aflibersept · Arsenik trioksit · Asparajin tüketicileri (Asparajinaz #/Pegaspargaz) · Aksikabtagen siloleusel · Belzutifan · Beksaroten · Breksukabtagen otolusel · Selekoksib · Siltaçabtagen otolusel · Demekolkolin · Denileukin diftitoks · Elesklomol § · Elsamitrusin · Enasidenib · Epakadostat · Eribulin · Estramustin fosfat · Glasdegib · İdekabtagen vikleusel · İvosidenib · Lonidamin · Lukantron · Lurbinektekin · Mitoguazon · Mitotan · Oblimersen † · Omaketaksin mepesuksinat · Plitidepsin · Retinoidler ( Alitretinoin · Selineksor · Sitimagene seradenovek · Sotorasib · Tagraksfusp · Talimogen laherparepvek · Tazemetostat · Tebentafusp · Tiazofurin · Tigilanol tiglat · Tisagenlekleusel · Trabektekin · Tretinoin#) · Veliparib · Venetoklaks · Verdineksor · Vosaroksin |
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