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Amelanotik melanom

Amelanotik melanom
Br köpeğin ayak parmağındaki amelanotik melanom
UzmanlıkOnkoloji, Dermatoloji Bunu Vikiveri'de düzenleyin

Amelanotik melanom, hücrelerin hiç melanin üretmediği bir deri kanseri türüdür.[1]:696[2] Bu tümörler pembe, kırmızı, mor veya normal ten rengine sahip olabilir ve bu nedenle bu tümörlere doğru teşhis konulması zordur. Bu tümörler normal melanom gibi vücudun herhangi bir yerinde oluşabilir.

Amelanotik melanomlar genellikle dermatit gibi benign lezyonlar, benign neoplastik durumlar veya bazal hücreli karsinom veya skuamöz hücre karsinomu gibi diğer malign durumlarla karıştırılır.[3] Amelanotik lezyonlar kötü prognozla ilişkilidir, bunun nedenlerinden birisi tanı koymadaki zorluktur; ancak metastatik amelanotik melanom diğer alt türlerden daha kötü prognoza sahiptir.[3]

Amelanotik melanom tanısından sonra hayatta kalma oranının, 2014'te 7 yıl boyunca 3000 hasta üzerinde yapılan bir çalışma sonucunda pigmentli melanomdan daha düşük olduğu tespit edilmiştir; bunun nedeni olarak muhtemelen tanı koymadaki zorluktan kaynaklanan kanser evresinin teşhisten sonra daha ileride olması gösterilmiştir. Ayrıca bu çalışma, amelanotik melanomların pigmentli melanomlardan daha hızlı büyüyebileceğine işaret etmiştir.[4]

Ayrıca bakınız

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  1. ^ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6. 
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1. 
  3. ^ a b Cabrera, Raúl; Recule, Francisca (2018). "Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings". American Journal of Clinical Dermatology. 19 (Suppl 1): 15-23. doi:10.1007/s40257-018-0373-6. ISSN 1175-0561. PMC 6244635 $2. PMID 30374898. 
  4. ^ Thomas, Nancy E.; Kricker, Anne; Waxweiler, Weston T.; Dillon, Patrick M.; Busam, Klaus J.; From, Lynn; Groben, Pamela A.; Armstrong, Bruce K.; Anton-Culver, Hoda; Gruber, Stephen B.; Marrett, Loraine D.; Gallagher, Richard P.; Zanetti, Roberto; Rosso, Stefano; Dwyer, Terence; Venn, Alison; Kanetsky, Peter A.; Orlow, Irene; Paine, Susan; Ollila, David W.; Reiner, Anne S.; Luo, Li; Hao, Honglin; Frank, Jill S.; Begg, Colin B.; Berwick, Marianne (2014). "Comparison of Clinicopathologic Features and Survival of Histopathologically Amelanotic and Pigmented Melanomas". JAMA Dermatology. 150 (12): 1306-1314. doi:10.1001/jamadermatol.2014.1348. ISSN 2168-6068. PMC 4262611 $2. PMID 25162299. 

Dış bağlantılar

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Amelanotik melanom
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