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Relaksinski receptor

Relaksin/insulinu-slična familija, peptidni receptor 1
Identifikatori
SimbolRXFP1
Alt. simboliLGR7
Entrez59350
HUGO19718
OMIM606654
RefSeqNM_021634
UniProtQ9HBX9
Ostali podaci
LokusHromozom 4 q31.3
Relaksin/insulinu-slična familija, peptidni receptor 2
Identifikatori
SimbolRXFP2
Alt. simboliLGR8, GREAT, GPR106, INSL3R
Entrez122042
HUGO17318
OMIM606655
RefSeqNM_130806
UniProtQ8WXD0
Ostali podaci
LokusHromozom 13 q12.3
Relaksin/insulinu-slična familija, peptidni receptor 3
Identifikatori
SimbolRXFP3
Alt. simboliRLN3R1, SALPR, GPCR135
Entrez51289
HUGO24883
OMIM609445
RefSeqNM_016568
UniProtQ9NSD7
Ostali podaci
LokusHromozom 5 p15.1-p14
Relaksin/insulinu-slična familija, peptidni receptor 4
Identifikatori
SimbolRXFP4
Alt. simboliGPR100, GPCR142, RLN3R2
Entrez339403
HUGO14666
OMIM609043
RefSeqNM_181885
UniProtQ8TDU9
Ostali podaci
LokusHromozom 1 q22

Relaksinski receptori su potklasa od četiri blisko srodna G protein-spregnuta receptora koji vezuju relaksinske peptidne hormone.[1][2]

Sledeća lista sadrži ljudske relaksinske receptore, njihove endogene peptidne hormone, i nizvodne enzime koji ss aktiviraju ili inhibiraju dejstvom ovih receptora.

receptor/gen ligandi aktivira inhibira
RXFP1 Relaksin 1, Relaksin 2, Relaksin 3 adenilat ciklaza, proteinska kinaza A, proteinska kinaza C,

fosfatidilinozitol 3-kinaza, ekstracelularnim signalom regulisane kinaze (Erk1/2)

RXFP2 Relaksin 1, Relaksin 2, INSL3 adenilat ciklaza
RXFP3 Relaksin 3 Erk1/2 signalizacija adenilat ciklaza
RXFP4 Relaksin 3, INSL3 adenilat ciklaza

Literatura

[уреди | уреди извор]
  1. ^ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides”. Pharmacol. Rev. 58 (1): 7—31. PMID 16507880. doi:10.1124/pr.58.1.9. 
  2. ^ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). „Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways”. Br. J. Pharmacol. 150 (6): 677—91. PMC 2013861 Слободан приступ. PMID 17293890. doi:10.1038/sj.bjp.0707140. 

Spoljašnje veze

[уреди | уреди извор]
Klasa A: Rodopsinu slični
Neurotransmiter
Adrenergički
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
Eikozanoidni
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
Neuropeptidni
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
Orfan
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
Orfan
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
Ukus
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
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Relaksinski receptor
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