Klonazepam
 | |
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Antelepsin, Antilepsin, Cloazepam, Clonopin |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 30-40 h |
| Izlučivanje | Renalno |
| Identifikatori | |
| CAS broj | 1622-61-3  |
| ATC kod | N03AE01 (WHO) |
| PubChem | CID 2802 |
| DrugBank | DB01068 |
| ChemSpider | 2700 |
| ChEBI | CHEBI:3756 |
| ChEMBL | CHEMBL452 |
| Hemijski podaci | |
| Formula | C15H10ClN3O3 |
| Molarna masa | 315,711 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | 2.365 °C (4.289 °F) |
Klonazepam (Rivotril) je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 315,711 Da.[1][2][3][4][5][6][7]
U prodaji je najčešće pod imenima Rivotril, ili ređe Klonopin.
Popularizacija zloupotrebe ovog leka je postala šira u periodu 2000ih, i dosta mladih ga rekreativno konzumira, zbog sedativno- anksiolitičkog dejstva koje poseduje, kao i osećaja euforije i "opuštenosti" koju izaziva.
Kao i svaki benzodiazepam, može izazvati veliki oblik zavisnosti.
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 2 |
| Particioni koeficijent[8] (ALogP) | 2,9 |
| Rastvorljivost[9] (logS, log(mol/L)) | -5,2 |
| Polarna površina[10] (PSA, Å2) | 87,3 |
Reference
[уреди | уреди извор]- ^ Dreifuss FE, Penry JK, Rose SW, Kupferberg HJ, Dyken P, Sato S: Serum clonazepam concentrations in children with absence seizures. Neurology. 1975 Mar;25(3):255-8. PMID 1089913
- ^ Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. PMID 7782744
- ^ Rosen GM, Turner MJ 3rd: Synthesis of spin traps specific for hydroxyl radical. J Med Chem. 1988 Feb;31(2):428-32. PMID 2828624
- ^ Rosen GM, Demos HA, Rauckman EJ: Not all aromatic nitro compounds form free radicals. Toxicol Lett. 1984 Aug;22(2):145-52. PMID 6089382
- ^ Earley JV, Fryer RI, Ning RY: Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci. 1979 Jul;68(7):845-50. PMID 458601
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
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