Gliceronfosfat O-aciltransferaza
| Gliceron-fosfat O-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.42 | ||||||||
| CAS broj | 37257-19-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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| Gliceronfosfat O-aciltransferaza | |
|---|---|
| Identifikatori | |
| Simbol | GNPAT |
| Entrez | 8443 |
| HUGO | 4416 |
| OMIM | 602744 |
| RefSeq | NM_014236 |
| UniProt | O15228 |
| Ostali podaci | |
| EC broj | 2.3.1.42 |
| Lokus | Hromozom 1 q42 |
Gliceron-fosfat O-aciltransferaza (EC 2.3.1.42, dihidroksiaceton fosfatna aciltransferaza) je enzim sa sistematskim imenom acil-KoA:gliceron-fosfat O-aciltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + gliceron fosfat KoA + acilgliceron fosfat
Ovaj enzim je membranski protein. On koristi KoA derivate palmitata, stearata i oleata. Najaktivniji je na palmitoil-KoA.
Gliceronfosfat O-aciltransferaza je enzim vezan za bolest rizomelna hondrodisplazija punktata, tip 2.[4]
Reference
[уреди | уреди извор]- ^ Ballas, L.M. & Bell, R.M. (1981). „Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles”. Biochim. Biophys. Acta. 665: 586—595. PMID 6271231.
- ^ Declercq, P.E., Haagsman, H.P., Van Veldhoven, P., Debeer, L.J., Van Golde, L.M.G. and Mannaerts, G.P. (1984). „Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis”. J. Biol. Chem. 259: 9064—9075. PMID 6746639.
- ^ Hajra, A.K. (1968). „Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria”. J. Biol. Chem. 243: 3458—3465. PMID 5656381.
- ^ Jan Velišek & Karel Cejpek. „Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids” (PDF). Czech J. Food Sci. 24: 241—254.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- glycerone-phosphate+O-acyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
- Glycerone-phosphate+O-acyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
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