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Bcl-2

B-ćelijski CLL/limfom 2
PDB prikaz bazairan na 1GJH​, 1G5M​.
Dostupne strukture
1G5M​, 1GJH​, 1YSW​, 2O21​, 2O22​, 2O2F​, 2W3L​, 2XA0​
Identifikatori
Simboli BCL2; Bcl-2; PPP1R50
Vanjski ID OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 596 12043
Ensembl ENSG00000171791 ENSMUSG00000057329
UniProt P10415 Q4VBF6
RefSeq (mRNA) NM_000633.2 NM_009741.3
RefSeq (protein) NP_000624.2 NP_033871.2
Lokacija (UCSC) Chr 18:
60.79 - 60.99 Mb		 Chr 1:
108.43 - 108.61 Mb
PubMed pretraga [1] [2]

Bcl-2 (B-ćelijski limfom 2) je član Bcl-2 familije proteinskih regulatora apoptoze. On je kodiran BCL2 genom.[1][2] Bcl-2 je drugi član niza proteina koji su inicijalno bili opisani u kontekstu hromozomske translokacije hromozoma 14 i 18 kod folikularnih limfoma. Bcl-2 ortolozi[3] postoje kod mnogobrojnih sisara. Dve izoforme Bcl-2, Izoforma 1, takođe poznata kao 1G5M, i Izoforma 2, poznata kao 1G5O/1GJH, imaju sličnu prostornu strukturu. Međutim, one se razlikuju u njihovoj sposobnosti vezivanja BAD u BAK proteina, kao i po strukturnoj topologiji i elektrostatičkom potencijalu vezujućeg žljeba. Iz toga sledi da Bcl-2 izoforme imaju različite antiapoptotičke aktivnosti.[4]

Interakcije

[уреди | уреди извор]

Bcl-2 formira interakcije sa RAD9A,[5] BAK1,[6][7] Retikulon 4,[8] Bcl-2 asocirani X protein,[5][6][9][10] Kaspaza 8,[11][12] BECN1,[13] SOD1,[14] Bcl-2 interagujući ubica,[15][16] BH3 interagujući domen agonista umiranja,[15][17] RRAS,[18] C-Raf,[19] BCL2L11,[15][20][21] BNIPL,[22][23] HRK,[15][24] PSEN1,[25] BMF,[26] BNIP2,[22][27] BNIP3,[27][28] Faktor rasta nerva IB,[6] BCL2-sličan 1,[6][29] Myc,[30] BCAP31,[31] SMN1,[32] CAPN2,[33] PPP2CA,[34] Noxa,[15][35] Cdk1,[36][37] TP53BP2,[38] Bcl-2 vezan promoter smrti[15][39] i IRS1.[40]

Ljudski BCL-2 geni

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BAK, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L14, BCL2L2,BCL2L7P1, BOK, MCL1, LGALS7 (Galektin-7)

Reference

[уреди | уреди извор]
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Vidi još

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Spoljašnje veze

[уреди | уреди извор]
Fas
Membrana
Fas ligand • Fas receptor
Intracelularno
Smrt-indukujući signalni kompleks

DAXX • ASK1

FADD • Kaspaza 8 • BID

Citohrom c • Kaspaza 9 • Kaspaza 3

pro-apoptotični: BAX • BAK1/Bcl-2 homologni antagonist ubica • Bcl-2-asocirani smrt promoter

anti-apoptotični: Bcl-2 • Bcl-xL
TNF
Membrana
Faktori nekroze tumora • Receptor faktora nekroze tumora
Intracelularno
TRADD

FADD • Kaspaza 8 • Kaspaza 3 • BID

TRAF2 • ASK-1 • MEKK1 • IKK • IκBα • MKK7 • JNK • NF-κB
Drugi
IAP
XIAP • NAIP • Survivin • c-IAP-1 • c-IAP-2
Apoptoza-indukujući faktor
Bcl-2 на Викимедијиној остави.
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Bcl-2
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