Neurotrofni moždani faktor
| Neurotrofni moždani faktor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| Dostupne strukture | |||||||||||
| 1B8M, 1BND | |||||||||||
| Identifikatori | |||||||||||
| Simboli | BDNF; ANON2; BULN2 | ||||||||||
| Vanjski ID | OMIM: 113505 MGI: 88145 HomoloGene: 7245 GeneCards: BDNF Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 627 | 12064 | |||||||||
| Ensembl | ENSG00000176697 | ENSMUSG00000048482 | |||||||||
| UniProt | P23560 | P21237 | |||||||||
| RefSeq (mRNA) | NM_001143805.1 | NM_001048139.1 | |||||||||
| RefSeq (protein) | NP_001137277.1 | NP_001041604.1 | |||||||||
| Lokacija (UCSC) |
Chr 11: 27.68 - 27.74 Mb |
Chr 2: 109.67 - 109.73 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Neurotrofni moždani faktor (BDNF) je sekretorni protein[2] koji je kod ljudi kodiran BDNF genom.[3][4] BDNF je član neurotrofinske familije faktora rasta, koja je srodna sa kanoničkim „nervnim faktorima rasta“, NGF. Neurotrofinski faktori su prisutni u mozgu i u perifernom nervnom sistemu.
Reference
[уреди | уреди извор]- ^ Robinson, R. C.; Radziejewski, C.; Stuart, D. I.; Jones, E. Y. (1995). „Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer”. Biochemistry. 34 (13): 4139—4146. PMID 7703225. doi:10.1021/bi00013a001.
- ^ Binder DK, Scharfman HE (2004). „Brain-derived Neurotrophic Factor”. Growth Factors. 22 (3): 123—31. PMC 2504526
. PMID 15518235. doi:10.1080/08977190410001723308.
- ^ Jones KR, Reichardt LF (1990). „Molecular cloning of a human gene that is a member of the nerve growth factor family”. Proc. Natl. Acad. Sci. U.S.A. 87 (20): 8060—4. Bibcode:1990PNAS...87.8060J. PMC 54892 . PMID 2236018. doi:10.1073/pnas.87.20.8060.
- ^ Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD (1991). „Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations”. Genomics. 10 (3): 558—68. PMID 1889806.
Spoljašnje veze
[уреди | уреди извор]- Cotman CW, Berchtold NC (28. 01. 2004). „BDNF and Alzheimer's Disease—What's the Connection?”. Alzforum: Live Discussions. Alzheimer Research Forum. Архивирано из оригинала 11. 10. 2008. г. Приступљено 21. 08. 2008.
- Patten-Hitt E (14. 06. 2001). „Brain-Derived Neurotrophic Factor (BDNF)”. Sciencexpress. The HDLighthouse, Huntingtons Disease: Information and Community. Архивирано из оригинала 25. 07. 2008. г. Приступљено 21. 08. 2008.
- Highfield R (18. 10. 2007). „Brain scans 'could reveal mental strength'”. Science. Telegraph.co.uk. Архивирано из оригинала 31. 05. 2008. г. Приступљено 21. 08. 2008. „Low BDNF activity promotes resilience”
| Endokrine žlezde |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neendokrine žlezde | Timus: Timozin (Timozin α1, Beta timozin) · Timopoietin · Timulin
Organi za varenje: Želudac: gastrin · grelin · Duodenum: CCK · GIP · sekretin · motilin · VIP · Ileum: enteroglukagon · peptid YY · Jetra/drugi: Insulinu sličan faktor rasta (IGF-1, IGF-2) Adipozno tkivo: leptin · adiponektin · rezistin Bubreg: JGA (renin) · peritubularne ćelije (EPO) · kalcitriol · prostaglandin Srce: Natriuretski peptid (ANP, BNP) | ||||||||||||||||
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