1466 (MCDLXVI) was a common year starting on Wednesday of the Julian calendar, the 1466th year of the Common Era (CE) and Anno Domini (AD) designations, the 466th year of the 2nd millennium, the 66th year of the 15th century, and the 7th year of the 1460s decade. As of the start of 1466, the Gregorian calendar was 9 days ahead of the Julian calendar, which was the dominant calendar of the time.

• June – Second Siege of Krujë: Mehmed II leads an army of 150,000 to stop the Albanian resistance by taking Krujë. The Albanians stop him and the Ottoman army leaves from Albania.
• August 26 – A conspiracy against Piero di Cosimo de' Medici, led by Luca Pitti and Borso d'Este, is discovered and put down in Florence.
• October 19 – The Thirteen Years' War ends

• The Chimú Empire is conquered by troops of the Inca.
• Erik Axelsson Tott replaces Jöns Bengtsson Oxenstierna as Regent of Sweden.
• The first printed German language Bible is made.
• Louis XI of France introduces silk weaving to Lyon.^[1]
• Kingdom of Georgia ends. Rival states of Kartli, Kakheti, Imereti, Samtskhe-Saatabago start.

• February 11 – Elizabeth of York, queen of Henry VII of England (d. 1503)
• June 18 – Ottaviano Petrucci, Italian music printer (d. 1539)
• August 10 – Francesco II Gonzaga, Marquess of Mantua (d. 1519)
• September 9 – Ashikaga Yoshitane, Japanese shogun (d. 1523)
• October 27 – Erasmus, Dutch philosopher (d. 1536)
• November 30 – Andrea Doria, Italian naval leader (d. 1560)
• probable
  • Moctezuma II, Aztec ruler of Tenochtitlán (d. 1520)
  • Alonso de Ojeda, Spanish conquistador and explorer (d. 1515)
    • Laura Bowen, founder of the nursing profession.

• March 8 – Francesco I Sforza, Duke of Milan (b. 1401)
• October 30 – Johann Fust, German printer (b. c. 1400)
• December 13 – Donatello, Italian artist (b. 1386)
• date unknown
  • Benedetto Accolti, Italian jurist and historian (b. 1415)
  • Hacı I Giray, first ruler of the Crimean Khanate
  • Barbara Manfredi, Italian noblewoman
  • Nicolaus Zacharie, composer