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Stopa infuzije

Izvor: Wikipedija

U farmakokinetici, stopa infuzije ili brzina doziranja se ne odnosi samo na brzinu kojom se lek unosi, več i na željenu brzinu kojom lek treba da bude administriran da bi se dostiglo stacionarno stanje fiksne doze za koju je pokazano da je terapeutski efektivna.

Ova veličina se u literaturi označava sa Kin,[1] K0,[2] ili R0.

Stopa infuzije se može izračunati kao koncentracija stacionarnog stanja u plazmi pomnožena sa klirensom:[3]

Reference

[uredi | uredi kod]
  1. „Cp vs time - iv infusion”. Arhivirano iz originala na datum 2008-04-25. 
  2. „Chapter 15.2 - Continuous IV Infusion - Steady State”. Arhivirano iz originala na datum 2013-10-22. 
  3. William E. Evans, Jerome J. Schentag, William J. Jusko (1999). Applied Pharmacokinetics, Principles of Therapeutic Drug Monitoring (3 izd.). Vancouver, Wa: Applied Therapeutics Inc. ISBN 0-915486-15-6. 
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Stopa infuzije
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