MuSK protein
Izvor: Wikipedija
| Mišićno skeletalna receptorska tirozinska kinaza | |
|---|---|
| Identifikatori | |
| Simbol | MUSK |
| Entrez | 4593 |
| Hugo | 7525 |
| OMIM | 601296 |
| RefSek | NM_005592 |
| UniProt | O15146 |
| Drugi podaci | |
| Lokus | Hrom. 9 q31.3-q32 |
MuSK (mišićno specifična kinaza) je receptorska tirozinska kinaza koja je neophodna za formiranje i održavanje neuromaskularnih spojeva. Ona se aktivira destvom nervnog proteoglikana, zvanog agrin.
Tokom razvića, rastući kraj motorno neuronskih aksona izlučuje protein agrin.[1] Ovaj protein se vezuje za nekoliko receptora na površini skeletalnih mišića. Receptor koji je neophodan za formiranje neuromuskularnog spoja, dela nervno-mišićne sinapse, je MuSK.[2] MuSK je receptorska tirozinska kinaza, te indukuje ćelijsku signalizaciju putem adicije fosfatnih molekula na specifične tirozine na sebi, i na proteinima koji se vezuju za citoplazmični domen receptora.
- ↑ Glass D et al. (1996). „Agrin acts via a MuSK receptor complex”. Cell 85 (4): 513–23. DOI:10.1016/S0092-8674(00)81252-0. PMID 8653787.
- ↑ DeChiara T et al. (1996). „The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo”. Cell 85 (4): 501–12. DOI:10.1016/S0092-8674(00)81251-9. PMID 8653786.
- N. Singhal, P. T. Martin: Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction. In: Developmental neurobiology. Band 71, Nummer 11, November 2011, S. 982–1005, ISSN 1932-846X. DOI:10.1002/dneu.20953. PMID 21766463. PMC 3472639. (Review).
- N. Ghazanfari, K. J. Fernandez u. a.: Muscle specific kinase: organiser of synaptic membrane domains. In: The international journal of biochemistry & cell biology. Band 43, Nummer 3, März 2011, S. 295–298, ISSN 1878-5875. DOI:10.1016/j.biocel.2010.10.008. PMID 20974278. (Review).
- R. Madhavan, H. B. Peng: Molecular regulation of postsynaptic differentiation at the neuromuscular junction. In: IUBMB life. Band 57, Nummer 11, November 2005, S. 719–730, ISSN 1521-6543. DOI:10.1080/15216540500338739. PMID 16511964. (Review).
- L. Strochlic, A. Cartaud, J. Cartaud: The synaptic muscle-specific kinase (MuSK) complex: new partners, new functions. In: BioEssays : news and reviews in molecular, cellular and developmental biology. Band 27, Nummer 11, November 2005, S. 1129–1135, ISSN 0265-9247. DOI:10.1002/bies.20305. PMID 16237673. (Review).
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