Furosemid
Izvor: Wikipedija
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| (IUPAC) ime | |||
|---|---|---|---|
| 4-hloro-2-(furan-2-ilmetilamino)- 5-sulfamoilbenzojeva kiselina | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 54-31-9 | ||
| ATC kod | C03CA01 | ||
| PubChem[1][2] | 3440 | ||
| DrugBank | DB00695 | ||
| ChemSpider[3] | 3322 | ||
| UNII | 7LXU5N7ZO5 
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| KEGG[4] | D00331
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| ChEBI | CHEBI:47426
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| ChEMBL[5] | CHEMBL35
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| Hemijski podaci | |||
| Formula | C12H11ClN2O5S | ||
| Mol. masa | 330,745 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakokinetički podaci | |||
| Bioraspoloživost | 43-69% | ||
| Metabolizam | hepatički i renalna glukuronidacija | ||
| Poluvreme eliminacije | do 100 minuta | ||
| Izlučivanje | renalno 66%, bilijarno 33% | ||
| Farmakoinformacioni podaci | |||
| Licenca |
US Daily Med:link | ||
| Trudnoća | C(AU) C(US) | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Oralno, IV, IM | ||
Furosemid[6] ili frusemid je diuretik Henleove petlje koji se koristi u tretmanu kongestivnog zatajenja srca i edema. Ovaj lek proizvodi i prodaje preduzeće Sanofi pod imenom Lasix. On je takođe dostupan pod imenima Fusid i Frumex.[7]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Changes to medicines names: BANs to rINNs
- ↑ Frumex
- Aventis Pharma (1998). Lasix Approved Product Information. Lane Cove: Aventis Pharma Pty Ltd.
- Barbara Forney (2007). Understanding Equine Medications, Revised Edition (Horse Health Care Library). Eclipse Press. ISBN 1-58150-151-X.
- Lasix and horse bleeding
- Furosemide in the Horse (Wind Publications) Arhivirano 2016-03-04 na Wayback Machine-u
- "Diuretics and other masking agents" Arhivirano 2007-09-26 na Wayback Machine-u (PDF) – Part S5 of the World Anti-Doping Agency's 2005 Prohibited List. International Standard.
- U.S. National Library of Medicine: Drug Information Portal - Furosemide
- Furosemide-A Practical Manual of Renal Medicine Arhivirano 2013-09-21 na Wayback Machine-u
Šablon:Diuretici
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