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CD70

Izvor: Wikipedija

CD70 molekul
Identifikatori
Simbol CD70
Alt. simboli CD27LG, TNFSF7
Entrez 970
HUGO 11937
OMIM 602840
RefSeq NM_001252
UniProt P32970
Drugi podaci
Lokus Hromozom 19 p13

CD70[1], ili Klaster diferencijacije 70, je ligand za CD27.[2] CD27, je član receptorske familije faktora nekroze tumora (TNF). CD70 vezivanje za CD27, indukuje T-ćelijsku kostimulaciju i B-ćelijsku aktivaciju. CD27 je izražen u neaktiviranim T i B ćelijama, dok je CD70 izražen u aktiviranim T i B ćelijama. Koristeći transfektirane glodarske pre-B-ćelijske linije koje izražavaju ljudski CD27 ili CD70, bilo je pokazano da CD70 povećava IgG produkciju.[2]

Vidi još

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Reference

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  1. „CD70 molecule”. 
  2. 2,0 2,1 Tetsuji Kobata, Serge Jacquot, Stacy Kozlowski, Kazunaga Agematsu, Stuart F. Schlossman, and Chikao Morimoto (1995). „CD27-CD70 interactions regulate B-cell activation by T cells”. Proc. Natl. Acad. Sci. USA 92: 11249-11253. [mrtav link]

Spoljašnje veze

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CD70
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