6-Tioinozinska kiselina
Izvor: Wikipedija
| 6-Tioinozinska kiselina | |||
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| IUPAC ime |
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| Identifikacija | |||
| CAS registarski broj | 53-83-8 | ||
| PubChem[1][2] | 3034391 | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C10H13N4O7PS | ||
| Molarna masa | 364.27 g/mol | ||
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| Infobox references | |||
Tioinozinska kiselina je intermedijar u metabolizmu azatioprina.[3] Azatioprin[4] je imunosupresivni lek koji se koadministrira sa ciclosporinom i kortikosteroidima da bi se sprečilo neprihvatanje transplantacije organa[5]. Azatioprin, prolek 6-mercaptopurina (6-MP), dejstvuje kao antimetabolit purina nakon intracelularne konverzije hipoksantinguanin fosforibosil transferazom u 6-tioinosine monofosfat (6-TIMP).
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ L Fletcher and J L Maddocks (1980). „Assay of thioinosinic acid, an active metabolite of azathioprine, in human lymphocytes.”. Br J Clin Pharmacol. 10 (3): 287–292.
- ↑ Thomas L. Lemke, David A. Williams, ur. (2002). Foye's Principles of Medicinal Chemistry (5 izd.). Baltimore: Lippincott Willams & Wilkins. str. 785-6. ISBN 0-7817-4443-1.
- ↑ Simmonds RL, Canafax DM, Fryd SD, Asher NL, Payne WD, Sutherland DER, Narajan JS (1986). „New immunosuppressive drug combination for mismatched related and cadaveric renal transplantation”. Transplant Proc 18: 76–81.
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