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Timidilato sintetase

thymidylate synthase
Timidilato sintetase
Homodímero de timidilato sintetase, Humana
Indicadores
Número EC 2.1.1.45
Número CAS
Bases de dados
IntEnz IntEnz
BRENDA BRENDA
ExPASy NiceZyme
KEGG KEGG
MetaCyc via metabólica
PRIAM PRIAM
Estruturas PDB RCSB PDB PDBe PDBj PDBsum
Gene Ontology AmiGO / EGO


Thymidylate synthase
Indicadores
Símbolo Thymidylat_synt
Pfam PF00303
InterPro IPR000398
PROSITE PDOC00086
SCOP 1tys

Timidilato sintetase (TS) (EC 2.1.1.45)[1] é uma enzima que catalisa a conversão de monofosfato de deoxiuridina (dUMP) a monofosfato de deoxitimidina (dTMP). Timidina é um dos nucleotídeos no DNA. Com inibição de TS, um desequilíbrio de desoxinucleotídeos e níveis aumentados de dUMP surgem. Ambos causam danos ao DNA.[2][3]

Referências

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Timidilato sintetase
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