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Receptor de glicocorticoides.
O receptor de glicocorticóides (GR, or GCR)também conhecido como NR3C1 (receptor nuclear subfamília 3, grupo C, membro 1) é o receptor ao qual cortisol e outros glicocorticoides se ligam.
O GR se expressa em quase todas as células do corpo e regula genes controlando o desenvolvimento biológico, metabolismo e sistema de resposta imunológica. Como o gene do receptor é expresso em várias formas, ele tem muitos efeitos diferentes (pleiotrópicos) em diferentes partes do corpo.
Quando o GR liga-se aos glicocorticoides, seu principal mecanismo de ação é a regulação da transcrição gênica.[1][2]
Referências
- ↑ Lu NZ, Wardell SE, Burnstein KL, Defranco D, Fuller PJ, Giguere V, Hochberg RB, McKay L, Renoir JM, Weigel NL, Wilson EM, McDonnell DP, Cidlowski JA (2006). «International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors». Pharmacol Revl. 58 (4): 782–97. PMID 17132855. doi:10.1124/pr.58.4.9 [Free full text]
- ↑ Rhen T, Cidlowski JA (outubro de 2005). «Antiinflammatory action of glucocorticoids--new mechanisms for old drugs». N. Engl. J. Med. 353 (16): 1711–23. PMID 16236742. doi:10.1056/NEJMra050541
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Receptor de glicocorticoides
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